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    Zfp873 zinc finger protein 873 [ Mus musculus (house mouse) ]

    Gene ID: 408062, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp873provided by MGI
    Official Full Name
    zinc finger protein 873provided by MGI
    Primary source
    MGI:MGI:3040689
    See related
    Ensembl:ENSMUSG00000061371 AllianceGenome:MGI:3040689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.2), CNS E14 (RPKM 1.8) and 22 other tissues See more
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    Genomic context

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    See Zfp873 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81883918..81914461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82048084..82077727)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10630 Neighboring gene predicted gene, 46195 Neighboring gene sorting nexin family member 27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2330 Neighboring gene cDNA sequence BC024063 Neighboring gene STARR-seq mESC enhancer starr_27356 Neighboring gene STARR-positive B cell enhancer ABC_E8351 Neighboring gene expressed sequence AU041133

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102234

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 873

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024626.2 → NP_001019797.2  zinc finger protein 873 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC171183, AK143655
      Consensus CDS
      CCDS83738.1
      UniProtKB/TrEMBL
      E9PU88
      Related
      ENSMUSP00000100950.2, ENSMUST00000105313.2
      Conserved Domains (3) summary
      COG5048
      Location:121 → 536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:473 → 498
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001319203.1 → NP_001306132.1  zinc finger protein 873 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC171183, BC090848
      Consensus CDS
      CCDS36009.2
      UniProtKB/TrEMBL
      A0A1B0GT64
      Related
      ENSMUSP00000148219.2, ENSMUST00000210325.2
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:158 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:510 → 535
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81883918..81914461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243504.4 → XP_011241806.1  zinc finger protein 873 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:158 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box

    2. XM_011243505.2 → XP_011241807.1  zinc finger protein 873 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:158 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box

    3. XM_017314022.2 → XP_017169511.1  zinc finger protein 873 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:81 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:386 → 406
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box
      pfam13465
      Location:511 → 535
      zf-H2C2_2; Zinc-finger double domain

    4. XM_036155884.1 → XP_036011777.1  zinc finger protein 873 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:121 → 536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_030245155.2 → XP_030101015.1  zinc finger protein 873 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:121 → 536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036155885.1 → XP_036011778.1  zinc finger protein 873 isoform X6

      Conserved Domains (3) summary
      COG5048
      Location:158 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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