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    IRF8 interferon regulatory factor 8 [ Gallus gallus (chicken) ]

    Gene ID: 396385, updated on 10-Oct-2024

    Summary

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    Symbol
    IRF8provided by CGNC
    Full Name
    interferon regulatory factor 8provided by CGNC
    Primary source
    CGNC:49782
    See related
    Ensembl:ENSGALG00010006715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ICSBP; ICSBP1
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See IRF8 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (17237123..17244589, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (17584730..17592148, complement)

    Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112533284 Neighboring gene uncharacterized LOC107054325 Neighboring gene dual specificity protein phosphatase 22-A-like Neighboring gene cytochrome c oxidase subunit 4I1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family. Jungwirth C, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7536924, Free PMC Article
    2. Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells. Hrdlicková R, et al. Mol Cell Biol, 2009 Feb. PMID 19047367, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon regulatory factor 8
    Names
    IRF-8
    interferon consensus sequence binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205416.1 → NP_990747.1  interferon regulatory factor 8

      See identical proteins and their annotated locations for NP_990747.1

      Status: PROVISIONAL

      Source sequence(s)
      L39767
      UniProtKB/Swiss-Prot
      Q90871
      UniProtKB/TrEMBL
      A0A8V0XZ20
      Conserved Domains (2) summary
      pfam00605
      Location:9 → 113
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:205 → 383
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      17237123..17244589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040707014.2 → XP_040562948.1  interferon regulatory factor 8 isoform X2

      Conserved Domains (1) summary
      smart00348
      Location:9 → 115
      IRF; interferon regulatory factor

    2. XM_015292551.4 → XP_015148037.1  interferon regulatory factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q90871
      UniProtKB/TrEMBL
      A0A8V0XZ20
      Related
      ENSGALP00010009233.1, ENSGALT00010016060.1
      Conserved Domains (2) summary
      pfam00605
      Location:9 → 113
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:205 → 383
      IRF-3; Interferon-regulatory factor 3

    3. XM_015292552.4 → XP_015148038.1  interferon regulatory factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q90871
      UniProtKB/TrEMBL
      A0A8V0XZ20
      Conserved Domains (2) summary
      pfam00605
      Location:9 → 113
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:205 → 383
      IRF-3; Interferon-regulatory factor 3

    4. XM_015292553.4 → XP_015148039.1  interferon regulatory factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q90871
      UniProtKB/TrEMBL
      A0A8V0XZ20
      Conserved Domains (2) summary
      pfam00605
      Location:9 → 113
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:205 → 383
      IRF-3; Interferon-regulatory factor 3

    5. XM_046899389.1 → XP_046755345.1  interferon regulatory factor 8 isoform X3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      17584730..17592148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046925372.1 → XP_046781328.1  interferon regulatory factor 8 isoform X2

    2. XM_046925369.1 → XP_046781325.1  interferon regulatory factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q90871

    3. XM_046925370.1 → XP_046781326.1  interferon regulatory factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q90871

    4. XM_046925371.1 → XP_046781327.1  interferon regulatory factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q90871

    5. XM_046925373.1 → XP_046781329.1  interferon regulatory factor 8 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90871.1 GenPept UniProtKB/Swiss-Prot:Q90871

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials