HES4 hes family bHLH transcription factor 4 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: HES4provided by CGNC
Official Full Name: hes family bHLH transcription factor 4provided by CGNC
Primary source: CGNC:49182
See related: Ensembl:ENSGALG00010021466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HES1; HAIRY1; c-Hey1; c-hairy-1; c-hairy1A
Orthologs: human all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (2796841..2799067)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (2828821..2831047)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hairy1 functions as a node downstream of Wnt signaling to maintain progenitor cells in the chick CMZ.
Title: Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.
Expressed in embryonic proventriculus. After day 6, restricted to luminal epithelium.
Title: Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse.
Results indicate that during chick somitogenesis Hairy1 may mediate gene transcriptional repression by recruiting the Sin3/HDAC complex, through a direct interaction with the Sap18 adaptor molecule.
Title: Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex.
These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos.
Title: Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor HES-4

Names: C-HAIRY1; c-hairy1B; hairy and enhancer of split 4; transcription factor HES-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005848.3 → NP_001005848.1 transcription factor HES-4 isoform 1

See identical proteins and their annotated locations for NP_001005848.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).

Source sequence(s)

JAENSK010000329

UniProtKB/Swiss-Prot

O57337

UniProtKB/TrEMBL

Q6XLQ0

Related

ENSGALP00010031068.1, ENSGALT00010052043.1

Conserved Domains (2) summary

cd00083
Location:33 → 96

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam07527
Location:111 → 148

Hairy_orange; Hairy Orange
NM_204472.4 → NP_989803.1 transcription factor HES-4 isoform 2

See identical proteins and their annotated locations for NP_989803.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1.

Source sequence(s)

JAENSK010000329

UniProtKB/Swiss-Prot

O57337

UniProtKB/TrEMBL

F1P2S5, Q6XLP9

Conserved Domains (2) summary

cd00083
Location:47 → 110

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam07527
Location:125 → 162

Hairy_orange; Hairy Orange