kcnk5b potassium channel, subfamily K, member 5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kcnk5bprovided by ZNC
Official Full Name: potassium channel, subfamily K, member 5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1297
See related: Ensembl:ENSDARG00000012390 AllianceGenome:ZFIN:ZDB-GENE-040426-1297
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kcnk5; zgc:63921
Summary: Enables outward rectifier potassium channel activity. Acts upstream of or within fin morphogenesis and regulation of membrane potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in fin; gill; heart; integument; and pleuroperitoneal region. Orthologous to human KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (9223514..9239034)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (9235775..9251295)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.
Title: The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.
A calcineurin-mediated scaling mechanism that controls a K(+)-leak channel to regulate morphogen and growth factor transcription.
Title: A calcineurin-mediated scaling mechanism that controls a K(+)-leak channel to regulate morphogen and growth factor transcription.
Here, we identify the potassium channel kcnk5b as a key player in integrating calcineurin's growth effects, in part through regulation of the cytoplasmic C-terminus of the channel.
Title: Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium channel subfamily K member 5b

Names: TASK-2b; alf; another longfin; potassium channel, subfamily K, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200633.1 → NP_956927.1 potassium channel subfamily K member 5b

See identical proteins and their annotated locations for NP_956927.1

Status: PROVISIONAL

Source sequence(s)

BC057416

UniProtKB/TrEMBL

Q6PFU3

Related

ENSDARP00000015031.6, ENSDART00000023293.7

Conserved Domains (3) summary

pfam00520
Location:142 → 234

Ion_trans; Ion transport protein

pfam07885
Location:81 → 137

Ion_trans_2; Ion channel

pfam16821
Location:258 → 323

C_Hendra; C protein from hendra and measles viruses