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    alg9 ALG9 alpha-1,2-mannosyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 393598, updated on 27-Mar-2024

    Summary

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    Official Symbol
    alg9provided by ZNC
    Official Full Name
    ALG9 alpha-1,2-mannosyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1270
    See related
    Ensembl:ENSDARG00000012840 AllianceGenome:ZFIN:ZDB-GENE-040426-1270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63820
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in central nervous system; epiphysis; polster; and retina. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See alg9 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (57743797..57763183)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (57073581..57092966)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene grass carp reovirus (GCRV)-induced gene 2p Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene protein phosphatase 2, regulatory subunit A, beta a Neighboring gene salt-inducible kinase 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. trappc11 is required for protein glycosylation in zebrafish and humans. DeRossi C, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912795, Free PMC Article
    2. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y, et al. Genes Dev, 2009 Mar 1. PMID 19240126, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63820

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase ALG9
    Names
    asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)
    NP_956919.2
    XP_009300116.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200625.2 → NP_956919.2  alpha-1,2-mannosyltransferase ALG9

      Status: VALIDATED

      Source sequence(s)
      BX901896, EH592472, EH609977
      UniProtKB/TrEMBL
      A0A8M1PER2, A5PMV6
      Related
      ENSDARP00000017149.7, ENSDART00000005090.9
      Conserved Domains (1) summary
      pfam03901
      Location:64 → 486
      Glyco_transf_22; Alg9-like mannosyltransferase family

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      57743797..57763183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301841.3 → XP_009300116.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZY9
      Conserved Domains (1) summary
      pfam03901
      Location:90 → 512
      Glyco_transf_22; Alg9-like mannosyltransferase family
    Nucleotide Protein Strain
    Heading Accession and Version

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