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    tbc1d5 TBC1 domain family, member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 393583, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tbc1d5provided by ZNC
    Official Full Name
    TBC1 domain family, member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1197
    See related
    Ensembl:ENSDARG00000036212 AllianceGenome:ZFIN:ZDB-GENE-040426-1197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63624
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be part of retromer complex. Predicted to be active in Golgi apparatus and endosome membrane. Is expressed in neural crest. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tbc1d5 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20404284..20446775, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20819961..20862476, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene raftlin, lipid raft linker 1a Neighboring gene deleted in azoospermia-like Neighboring gene SATB homeobox 1a Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63624

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328258.1 → NP_001315187.1  TBC1 domain family member 5

      Status: VALIDATED

      Source sequence(s)
      BX927400
      UniProtKB/TrEMBL
      A0A8M1P8X8, F1QXM3, J9JI17
      Related
      ENSDARP00000122022.2, ENSDART00000140711.3
      Conserved Domains (1) summary
      smart00164
      Location:71 → 373
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      20404284..20446775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170012.4 → XP_005170069.1  TBC1 domain family member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHA5
      Conserved Domains (1) summary
      smart00164
      Location:71 → 373
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200611.1: Suppressed sequence

      Description
      NM_200611.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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