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    adat3 adenosine deaminase tRNA specific 3 [ Danio rerio (zebrafish) ]

    Gene ID: 368634, updated on 2-Nov-2024

    Summary

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    Official Symbol
    adat3provided by ZNC
    Official Full Name
    adenosine deaminase tRNA specific 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-531
    See related
    Ensembl:ENSDARG00000005640 AllianceGenome:ZFIN:ZDB-GENE-030616-531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:103555; si:dz72b14.5; si:dkey-204g5.2; si:busm1-72b14.5
    Summary
    Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to act upstream of or within tRNA processing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See adat3 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (41035925..41040492, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (41234138..41238705, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-3o3.7 Neighboring gene myostatin b Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene ORMDL sphingolipid biosynthesis regulator 1 Neighboring gene O-sialoglycoprotein endopeptidase-like 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene U5 spliceosomal RNA Neighboring gene zgc:136439 Neighboring gene asparagine synthetase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC103555

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable inactive tRNA-specific adenosine deaminase-like protein 3
    Names
    tRNA-specific adenosine-34 deaminase subunit adat3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005300.3 → NP_001005300.2  probable inactive tRNA-specific adenosine deaminase-like protein 3

      See identical proteins and their annotated locations for NP_001005300.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT737230
      UniProtKB/Swiss-Prot
      B0V342, Q8JFR8, Q8JFW4
      UniProtKB/TrEMBL
      A0A8M1P0S6, Z4YHM2
      Related
      ENSDARP00000018770.5, ENSDART00000008275.8
      Conserved Domains (1) summary
      COG0590
      Location:167 → 336
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    2. NM_001293177.1 → NP_001280106.1  probable inactive tRNA-specific adenosine deaminase-like protein 3

      See identical proteins and their annotated locations for NP_001280106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT737230
      UniProtKB/Swiss-Prot
      B0V342, Q8JFR8, Q8JFW4
      UniProtKB/TrEMBL
      A0A8M1P0S6, Z4YHM2
      Related
      ENSDARP00000137501.1, ENSDART00000163164.2
      Conserved Domains (1) summary
      COG0590
      Location:167 → 336
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      41035925..41040492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JFW4.2 GenPept UniProtKB/Swiss-Prot:Q8JFW4

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