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    tfpia tissue factor pathway inhibitor a [ Danio rerio (zebrafish) ]

    Gene ID: 359833, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tfpiaprovided by ZNC
    Official Full Name
    tissue factor pathway inhibitor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030711-1
    See related
    Ensembl:ENSDARG00000034718 AllianceGenome:ZFIN:ZDB-GENE-030711-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TFPI; tfpib; wu:fb92g01; zgc:152844; zgc:158592; si:dz44f8.1
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within hemostasis and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin skeleton. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See tfpia in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (42420636..42484444, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (42618849..42682657, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkey-10c21.1 Neighboring gene uncharacterized LOC103911686 Neighboring gene calcitonin receptor-like a Neighboring gene uncharacterized LOC137496414 Neighboring gene uncharacterized LOC137496413 Neighboring gene uncharacterized LOC137496417 Neighboring gene GULP PTB domain containing engulfment adaptor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish. Raman R, et al. Thromb Haemost, 2022 Jul. PMID 34918310
    2. 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Schmid S, et al. Environ Pollut, 2020 Apr. PMID 31887585
    3. Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. Martins R, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 24815885
    4. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
    5. Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis. Wang L, et al. FASEB J, 2018 Jan. PMID 28877957, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tissue factor pathway inhibitor a
    Names
    coagulation inhibitor
    lipoprotein-associated
    tissue factor pathway inhibitor b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309803.1 → NP_001296732.1  tissue factor pathway inhibitor a isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX470245, CT943665
      UniProtKB/TrEMBL
      A0A8M1P282, B0S6C1
      Related
      ENSDARP00000047652.6, ENSDART00000047653.8
      Conserved Domains (2) summary
      cd00109
      Location:99 → 151
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:42 → 92
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. NM_182872.2 → NP_878292.2  tissue factor pathway inhibitor a isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BX470245, CT943665
      UniProtKB/TrEMBL
      A0A8M1PAQ1, E7EXD1
      Related
      ENSDARP00000048319.7, ENSDART00000048320.7
      Conserved Domains (2) summary
      cd00109
      Location:98 → 150
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:41 → 91
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      42420636..42484444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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