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    mtif3 mitochondrial translational initiation factor 3 [ Danio rerio (zebrafish) ]

    Gene ID: 325802, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mtif3provided by ZNC
    Official Full Name
    mitochondrial translational initiation factor 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060228-1
    See related
    Ensembl:ENSDARG00000039649 AllianceGenome:ZFIN:ZDB-GENE-060228-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd12b09; wu:fd12b09; si:ch211-271b14.5
    Summary
    Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Predicted to act upstream of or within translational initiation. Predicted to be active in mitochondrion. Orthologous to human MTIF3 (mitochondrial translational initiation factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mtif3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (67971627..67978844)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (67293916..67301133)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 10, depalmitoylase a Neighboring gene GS homeobox 1 Neighboring gene general transcription factor IIIAa Neighboring gene WASP family member 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Duplication and subfunctionalisation of the general transcription factor IIIA (gtf3a) gene in teleost genomes, with ovarian specific transcription of gtf3ab. Rojo-Bartolomé I, et al. PLoS One, 2020. PMID 31999691, Free PMC Article
    2. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor IF-3, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326363.1 → NP_001313292.1  translation initiation factor IF-3, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BX247876, EH490717, EH600958
      UniProtKB/TrEMBL
      A0A8M1P7U4, A2BEV1
      Related
      ENSDARP00000122353.1, ENSDART00000144879.3
      Conserved Domains (3) summary
      TIGR00168
      Location:86 → 240
      infC; translation initiation factor IF-3
      pfam00707
      Location:162 → 197
      IF3_C; Translation initiation factor IF-3, C-terminal domain
      pfam05198
      Location:83 → 152
      IF3_N; Translation initiation factor IF-3, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      67971627..67978844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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