U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Coq5 coenzyme Q5, methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304542, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Coq5provided by RGD
    Official Full Name
    coenzyme Q5, methyltransferaseprovided by RGD
    Primary source
    RGD:1310857
    See related
    EnsemblRapid:ENSRNOG00000001171 AllianceGenome:RGD:1310857
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310857
    Summary
    Predicted to enable 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of ubiquinone biosynthesis complex. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 192.1), Adrenal (RPKM 144.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Coq5 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46977632..46994575, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41316922..41333855, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47078753..47095438, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 9 Neighboring gene dynein light chain LC8-type 1 Neighboring gene uncharacterized LOC120096006 Neighboring gene ring finger protein 10 Neighboring gene POP5 homolog, ribonuclease P/MRP subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Nguyen TP, et al. Biochim Biophys Acta, 2014 Nov. PMID 25152161, Free PMC Article
    2. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC112711

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
    Names
    coenzyme Q5 homolog, methyltransferase
    ubiquinone biosynthesis methyltransferase COQ5, mitochondrial
    NP_001034111.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039022.1 → NP_001034111.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001034111.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098719
      UniProtKB/Swiss-Prot
      Q4G064
      Related
      ENSRNOP00000001547.4, ENSRNOT00000001546.8
      Conserved Domains (1) summary
      PRK00216
      Location:56 → 327
      ubiE; bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      46977632..46994575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005491629.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G064.1 GenPept UniProtKB/Swiss-Prot:Q4G064

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous