tdgf1 teratocarcinoma-derived growth factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tdgf1provided by ZNC
Official Full Name: teratocarcinoma-derived growth factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-198
See related: Ensembl:ENSDARG00000035095 AllianceGenome:ZFIN:ZDB-GENE-990415-198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: oep; cb85; cripto; wu:fe01d04; zgc:109829
Summary: Predicted to enable activin receptor binding activity and nodal binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Located in external side of plasma membrane. Is expressed in several structures, including EVL; cardiovascular system; diencephalon; ectoderm; and mesoderm. Used to study neural tube defect. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (1955474..1961930, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (1927760..1934216, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.
Title: A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.
The pattern of nodal morphogen signaling is shaped by co-receptor expression.
Title: The pattern of nodal morphogen signaling is shaped by co-receptor expression.
Myosin II, and upstream ROCK1/2 activities are required for localization of Cripto to cytoplasm/membrane domains and its subsequent release into the conditioned media fraction of cultured cells. Soluble Cripto (one-eyed pinhead in zebrafish) promotes proliferation in mesenchymal stem cells (MSCs) and stem cell-mediated wound healing in the zebrafish caudal fin model of regeneration.
Title: Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration.
Reduced expression of Oep causes the loss of responsiveness to Nodal signals in the prospective ectoderm. Indeed, extending the presence of Oep prolongs the window of competence to respond to Nodal signals.
Title: Reduced expression of the Nodal co-receptor Oep causes loss of mesendodermal competence in zebrafish.
Late zygotic oep mutants have strongly reduced or absent pitx2 expression in the lateral plate mesoderm (LPM), but this expression can be rescued to strong levels by restoring oep in midline structures only.
Title: Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning.
Nodal-BMP signaling cascade drives left-right heart morphogenesis by regulating the speed and direction of cardiomyocyte movement
Title: Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish.
Using mutants in the Nodal receptor cofactor one-eyed pinhead (oep) and the T-box transcription factors spadetail (spt) and no tail (ntl), we were able to define distinctive regulation underlying these sequential phases of PGP midline migration
Title: Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis.
heterozygote mutations in fgf8, shh or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease
Title: Heterozygous mutations in the FGF8, SHH and nodal/transforming growth factor beta pathways do not confer increased dopaminergic neuron vulnerability--a zebrafish study.
Vg1 and GDF1 signaling require one-eyed pinhead.
Title: EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1.
Interplay between FGF, one-eyed pinhead (zoep), and T-box transcription factors spt and ntl during zebrafish posterior
Title: Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

fe01d04.x1 (e-PCR)
- UniSTS:195906

oep (e-PCR), detects polymorphism
- UniSTS:187010

Z6410 (e-PCR)
- UniSTS:204690

oep (e-PCR), detects polymorphism
- UniSTS:205553

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables activin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nodal binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast migration to the midline involved in heart field formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in nephron morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of digestive tract development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endocrine pancreas development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate formation	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within floor plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within hypoblast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypothalamus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within induction of positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens placode formation involved in camera-type eye formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of liver development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mesendoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesoderm formation	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural plate anterior/posterior regionalization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nodal signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nodal signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of pharyngeal system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of developmental process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within prechordal plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric glomerulus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within telencephalon development	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: teratocarcinoma-derived growth factor 1

Names: one-eyed pinhead

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328408.1 → NP_001315337.1 teratocarcinoma-derived growth factor 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

BC152111, CABZ01070744

UniProtKB/TrEMBL

A0A8M1PA94, A7MCB2

Related

ENSDARP00000106724.1, ENSDART00000122446.4

Conserved Domains (2) summary

cd00054
Location:84 → 108

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam09443
Location:116 → 150

CFC; Cripto_Frl-1_Cryptic (CFC)
NM_131092.2 → NP_571167.2 teratocarcinoma-derived growth factor 1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CABZ01070743, CABZ01070744

UniProtKB/TrEMBL

A0A8M1PBB6, F1Q691