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    TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]

    Gene ID: 28951, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIB2provided by HGNC
    Official Full Name
    tribbles pseudokinase 2provided by HGNC
    Primary source
    HGNC:HGNC:30809
    See related
    Ensembl:ENSG00000071575 MIM:609462; AllianceGenome:HGNC:30809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5FW; TRB2; GS3955
    Summary
    This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 31.3), spleen (RPKM 27.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIB2 in Genome Data Viewer
    Location:
    2p24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (12716936..12742734)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (12746001..12771799)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (12857062..12882860)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MIR3681 host gene Neighboring gene uncharacterized LOC107985853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11181 Neighboring gene NANOG hESC enhancer GRCh37_chr2:12714950-12715488 Neighboring gene MPRA-validated peak3595 silencer Neighboring gene Sharpr-MPRA regulatory region 12883 Neighboring gene MPRA-validated peak3596 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:12766335-12766899 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:12804005-12804220 Neighboring gene uncharacterized LOC124905974 Neighboring gene CRISPRi-validated cis-regulatory element chr2.599 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:12856972-12857611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11182 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:12858891-12859528 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:12866409-12867608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:12909653-12910503 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:12956433-12957632 Neighboring gene microRNA 3125 Neighboring gene CRISPR/Cas9-targeted silencer 9 Neighboring gene uncharacterized LOC100506474 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:13120952-13121455 Neighboring gene uncharacterized LOC105373436 Neighboring gene uncharacterized LOC105373484

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia. Tan SH, et al. Leukemia, 2016 Apr. PMID 26202930, Free PMC Article
    2. Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Eder K, et al. Int Immunol, 2008 Dec. PMID 18952906, Free PMC Article
    3. Knockdown of circ_0084043 suppresses the development of human melanoma cells through miR-429/tribbles homolog 2 axis and Wnt/β-catenin pathway. Chen Z, et al. Life Sci, 2020 Feb 15. PMID 31954160
    4. Trib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiency. Do EK, et al. Exp Mol Med, 2017 Nov 24. PMID 29170476, Free PMC Article
    5. Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer. Kritsch D, et al. Int J Cancer, 2017 Oct 15. PMID 28670762

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance.
      Title: TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance.
    2. Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2.
      Title: Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2.
    3. Upregulation of Tribbles decreases body weight and increases sleep duration.
      Title: Upregulation of Tribbles decreases body weight and increases sleep duration.
    4. TRIB2 safeguards naive T cell homeostasis during aging.
      Title: TRIB2 safeguards naive T cell homeostasis during aging.
    5. Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.
      Title: Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.
    6. Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
      Title: Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
    7. Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.
      Title: Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.
    8. Potential innate immunity-related markers of endometrial receptivity and recurrent implantation failure (RIF).
      Title: Potential innate immunity-related markers of endometrial receptivity and recurrent implantation failure (RIF).
    9. A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma.
      Title: A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma.
    10. TRIB2 Stimulates Cancer Stem-Like Properties through Activating the AKT-GSK3beta-beta-Catenin Signaling Axis.
      Title: TRIB2 Stimulates Cancer Stem-Like Properties through Activating the AKT-GSK3β-β-Catenin Signaling Axis.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ57420

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ubiquitin-protein transferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tribbles homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011644.1 RefSeqGene

      Range
      5065..30863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021643.4 → NP_067675.1  tribbles homolog 2

      See identical proteins and their annotated locations for NP_067675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC009486
      Consensus CDS
      CCDS1683.1
      UniProtKB/Swiss-Prot
      B2R851, D6W510, Q92519
      Related
      ENSP00000155926.4, ENST00000155926.9
      Conserved Domains (1) summary
      cd14022
      Location:67 → 308
      PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

    RNA

    1. NR_027303.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks the translational start codon used in variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009486, AK129973, AK299146, AY245544, D87119
      Related
      ENST00000381465.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      12716936..12742734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      12746001..12771799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92519.1 GenPept UniProtKB/Swiss-Prot:Q92519

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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