PDIA3 protein disulfide isomerase family A member 3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PDIA3provided by VGNC
Official Full Name: protein disulfide isomerase family A member 3provided by VGNC
Primary source: VGNC:VGNC:32697
See related: BGD:BT15601; Ensembl:ENSBTAG00000017196
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: GRP58
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (55370251..55392459)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDIA3 may play in the progression of heart failure.
Title: Serendipitous discovery of a novel protein signaling mechanism in heart failure.

Submit: New GeneRIF Correction

General gene information

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Markers

GRP58 (e-PCR)
- UniSTS:519322

stSG627936 (e-PCR)
- UniSTS:457929

GRP58 (e-PCR)
- UniSTS:278502

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein folding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein disulfide-isomerase A3

Names: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; ER protein 57; ER protein 60; ERP60; ERp57; disulfide isomerase ER-60; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; glucose regulated protein 58kD; p58

NP_776758.2

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174333.3 → NP_776758.2 protein disulfide-isomerase A3 precursor

See identical proteins and their annotated locations for NP_776758.2

Status: PROVISIONAL

Source sequence(s)

BC140529

UniProtKB/Swiss-Prot

P38657

UniProtKB/TrEMBL

A5D7E8

Related

ENSBTAP00000022854.4, ENSBTAT00000022854.5

Conserved Domains (1) summary

cl27119
Location:25 → 487

YbbN; Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains [Posttranslational modification, protein turnover, chaperones]