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    hip1 histone chaperone Hip1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540219, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hip1
    Official Full Name
    histone chaperone Hip1
    Primary source
    PomBase:SPBC31F10.13c
    Locus tag
    SPOM_SPBC31F10.13C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    hir1
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    Genomic context

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    See hip1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003423.3 (3774138..3777421, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Cwf4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA-binding protein Tma20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene histone chaperone Hip3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The impact of the HIRA histone chaperone upon global nucleosome architecture. Gal C, et al. Cell Cycle, 2015. PMID 25602522, Free PMC Article
    2. HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast. Chujo M, et al. J Biol Chem, 2012 Jul 6. PMID 22589550, Free PMC Article
    3. The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts. Anderson HE, et al. Mol Cell Biol, 2009 Sep. PMID 19620282, Free PMC Article
    4. Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for transcriptional silencing and accurate chromosome segregation. Greenall A, et al. J Biol Chem, 2006 Mar 31. PMID 16428807
    5. The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres. Blackwell C, et al. Mol Cell Biol, 2004 May. PMID 15121850, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIRA protein plays roles in the maintenance of both euchromatic and heterochromatic regions of the genome.
      Title: The impact of the HIRA histone chaperone upon global nucleosome architecture.
    2. Studies indicate that the fission yeast possesses two HIRA proteins Slm9 and Hip1.
      Title: HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast.
    3. HIRA histone chaperone is required to maintain the protective functions of chromatin.
      Title: The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.
    4. crystallographic analysis of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (Hip1B) and the C-terminal region of the Cac2 subunit of CAF-1 (Cac2C)
      Title: Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to H3-H4 histone complex chaperone activity IC
    Inferred by Curator
    more info
    		  
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HIR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone chaperone Hip1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3774138..3777421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022496.3 → NP_596575.1  histone chaperone Hip1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596575.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87314, Q9US78
      Conserved Domains (5) summary
      COG2319
      Location:15 → 348
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:15 → 348
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07569
      Location:663 → 878
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:475 → 495
      HIRA_B; HIRA B motif
      sd00039
      Location:21 → 69
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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