mab21l1 mab-21-like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mab21l1provided by ZNC
Official Full Name: mab-21-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020516-1
See related: Ensembl:ENSDARG00000102047 AllianceGenome:ZFIN:ZDB-GENE-020516-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable metal ion binding activity; nucleotide binding activity; and nucleotidyltransferase activity. Acts upstream of or within cornea development in camera-type eye. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; immature eye; nervous system; neural tube; and pharyngeal arch 3-7. Orthologous to human MAB21L1 (mab-21 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (33070939..33073200)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (33212960..33215221)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways.
Title: Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways.
Despite the absence of conserved non-coding elements, a 4.9-kb mab21l2 promoter is sufficient to recapitulate expression in tissues unique to mab21l1 or mab21l2.
Title: mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation.
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
Title: Expression of ventral diencephalon-enriched genes in zebrafish.
mab21 genes play a role in differentiation of the early differentiating olfactory bulbs, eye primordia, midbrain and subsequently the branchial pouches and neural tube
Title: Expression of zebrafish mab21 genes marks the differentiating eye, midbrain and neural tube.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cornea development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative nucleotidyltransferase MAB21L1

Names: protein mab-21-like 1

NP_694506.2

EC 2.7.7.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.