Tmprss11d transmembrane protease, serine 11d [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss11dprovided by MGI
Official Full Name: transmembrane protease, serine 11dprovided by MGI
Primary source: MGI:MGI:2385221
See related: Ensembl:ENSMUSG00000061259 AllianceGenome:MGI:2385221
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AST; AsP
Summary: Predicted to enable serine-type peptidase activity. Involved in proteolysis. Predicted to be located in cell surface. Is expressed in adrenal gland; epithelium; and trunk. Orthologous to human TMPRSS11D (transmembrane serine protease 11D). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86450713..86521246, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86302854..86373387, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.
Title: TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.
A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed.
Title: Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.
Predominantly expressed in upper gastrointestinal and respiratory tract-but also in adrenal gland. Complex expression pattern. Multifunctional role beyond adrenal proliferation.
Title: The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

Tmprss11d (e-PCR), detects polymorphism
- UniSTS:498752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within symbiont entry into host cell	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 11D

Names: AT; adrenal secretory serine protease; airway spesific trypsin-like protease; airway trypsin-like protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145561.2 → NP_663536.1 transmembrane protease serine 11D

See identical proteins and their annotated locations for NP_663536.1

Status: PROVISIONAL

Source sequence(s)

AC098885, AC100746

Consensus CDS

CCDS39124.1

UniProtKB/Swiss-Prot

Q7TNX3, Q8VDV1, Q8VHK8

Related

ENSMUSP00000031175.6, ENSMUST00000031175.12

Conserved Domains (3) summary

smart00020
Location:185 → 411

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:186 → 414

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:48 → 140

SEA; SEA domain