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    Ube2e2 ubiquitin-conjugating enzyme E2E 2 [ Mus musculus (house mouse) ]

    Gene ID: 218793, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ube2e2provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2E 2provided by MGI
    Primary source
    MGI:MGI:2384997
    See related
    Ensembl:ENSMUSG00000058317 AllianceGenome:MGI:2384997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in protein modification by small protein conjugation. Predicted to act upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including eye; genitourinary system; gut; integumental system; and nervous system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human UBE2E2 (ubiquitin conjugating enzyme E2 E2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.9), cortex adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2e2 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (3575429..3896133)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18573563..18894284, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene clusterin like 1, pseudogene 2 Neighboring gene kinesin family member 2C pseudogene Neighboring gene STARR-seq mESC enhancer starr_36061 Neighboring gene STARR-seq mESC enhancer starr_36060 Neighboring gene aurora kinase A pseudogene Neighboring gene predicted gene, 22499 Neighboring gene STARR-seq mESC enhancer starr_36059 Neighboring gene STARR-seq mESC enhancer starr_36058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:19498168-19498444 Neighboring gene STARR-seq mESC enhancer starr_36056 Neighboring gene STARR-seq mESC enhancer starr_36055 Neighboring gene STARR-seq mESC enhancer starr_36054 Neighboring gene predicted gene, 32587 Neighboring gene vacuolar protein sorting 4b pseudogene Neighboring gene farnesyl diphosphate farnesyl transferase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass. Sakurai Y, et al. Diabetes, 2024 Mar 1. PMID 38064504
    2. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of UBE2E2 in Mouse Pancreatic beta-Cells Leads to Glucose Intolerance via Reduction of beta-Cell Mass.
      Title: Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28917

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ISG15 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ISG15 transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ISG15 transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ISG15-protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ISG15-protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 E2
    Names
    E2 ubiquitin-conjugating enzyme E2
    TBC1 domain family, member 12
    ubiquitin carrier protein E2
    ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
    ubiquitin-protein ligase E2
    NP_001347256.1
    NP_001347257.1
    NP_659088.1
    XP_006518075.1
    XP_017171445.1
    XP_017171446.1
    XP_017171447.1
    XP_017171448.1
    XP_017171449.1
    XP_036014440.1
    XP_036014441.1
    XP_036014442.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360327.1 → NP_001347256.1  ubiquitin-conjugating enzyme E2 E2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118006, AW495303, BY290283, CF732742, DN172861
      Consensus CDS
      CCDS26838.1
      UniProtKB/Swiss-Prot
      Q91W82
      Related
      ENSMUSP00000075495.4, ENSMUST00000076133.10
      Conserved Domains (1) summary
      pfam00179
      Location:59 → 196
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001360328.1 → NP_001347257.1  ubiquitin-conjugating enzyme E2 E2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AW495303, BY250357, CF732742, CX208846
      UniProtKB/TrEMBL
      D3YXD1
      Related
      ENSMUSP00000118321.2, ENSMUST00000151926.8
      Conserved Domains (1) summary
      pfam00179
      Location:83 → 220
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_144839.2 → NP_659088.1  ubiquitin-conjugating enzyme E2 E2 isoform 1

      See identical proteins and their annotated locations for NP_659088.1

      Status: VALIDATED

      Source sequence(s)
      AC118006, AW495303, BY752670, CF732742, DN172861
      Consensus CDS
      CCDS26838.1
      UniProtKB/Swiss-Prot
      Q91W82
      Related
      ENSMUSP00000115738.2, ENSMUST00000150727.8
      Conserved Domains (1) summary
      pfam00179
      Location:59 → 196
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      3575429..3896133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158547.1 → XP_036014440.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

      Conserved Domains (1) summary
      pfam00179
      Location:59 → 202
      UQ_con; Ubiquitin-conjugating enzyme

    2. XM_017315958.3 → XP_017171447.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

      Conserved Domains (1) summary
      pfam00179
      Location:59 → 210
      UQ_con; Ubiquitin-conjugating enzyme

    3. XM_036158549.1 → XP_036014442.1  ubiquitin-conjugating enzyme E2 E2 isoform X6

      Conserved Domains (1) summary
      pfam00179
      Location:48 → 179
      UQ_con; Ubiquitin-conjugating enzyme

    4. XM_006518012.4 → XP_006518075.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

      Conserved Domains (1) summary
      pfam00179
      Location:59 → 202
      UQ_con; Ubiquitin-conjugating enzyme

    5. XM_017315960.3 → XP_017171449.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

      Conserved Domains (1) summary
      pfam00179
      Location:59 → 210
      UQ_con; Ubiquitin-conjugating enzyme

    6. XM_036158548.1 → XP_036014441.1  ubiquitin-conjugating enzyme E2 E2 isoform X6

      Conserved Domains (1) summary
      pfam00179
      Location:48 → 179
      UQ_con; Ubiquitin-conjugating enzyme

    7. XM_017315957.3 → XP_017171446.1  ubiquitin-conjugating enzyme E2 E2 isoform X2

      Conserved Domains (1) summary
      pfam00179
      Location:83 → 226
      UQ_con; Ubiquitin-conjugating enzyme

    8. XM_017315956.3 → XP_017171445.1  ubiquitin-conjugating enzyme E2 E2 isoform X1

      Conserved Domains (1) summary
      pfam00179
      Location:83 → 234
      UQ_con; Ubiquitin-conjugating enzyme

    9. XM_017315959.3 → XP_017171448.1  ubiquitin-conjugating enzyme E2 E2 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:72 → 203
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. XR_004938379.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W82.1 GenPept UniProtKB/Swiss-Prot:Q91W82

    Gene LinkOut

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