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    Sstr3 somatostatin receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 20607, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sstr3provided by MGI
    Official Full Name
    somatostatin receptor 3provided by MGI
    Primary source
    MGI:MGI:98329
    See related
    Ensembl:ENSMUSG00000044933 AllianceGenome:MGI:98329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sst3; Smstr3; Smstr-3
    Summary
    Enables signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Located in ciliary membrane; neuron projection; and non-motile cilium. Is expressed in several structures, including central nervous system; cochlea; gallbladder; genitourinary system; and gut. Orthologous to human SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 2.1) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sstr3 in Genome Data Viewer
    Location:
    15 E1; 15 37.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78421214..78433565, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78537014..78549365, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene interleukin 2 receptor, beta chain Neighboring gene C1q and tumor necrosis factor related protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E4139 Neighboring gene STARR-seq mESC enhancer starr_39149 Neighboring gene L antigen family, member 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78394443-78394712 Neighboring gene Rac family small GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78402050-78402237 Neighboring gene STARR-positive B cell enhancer ABC_E11809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. Yasuda K, et al. J Biol Chem, 1992 Oct 5. PMID 1328199
    2. Somatostatin receptor-3 mediated intracellular signaling and apoptosis is regulated by its cytoplasmic terminal. War SA, et al. Biochim Biophys Acta, 2011 Mar. PMID 21194548
    3. Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice. Iwanaga T, et al. Biomed Res, 2011 Feb. PMID 21383513
    4. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3. Adamson SE, et al. Islets, 2023 Dec 31. PMID 37660302, Free PMC Article
    5. Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3. Tower-Gilchrist C, et al. Biochem Biophys Res Commun, 2011 Oct 7. PMID 21925142, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
      Title: Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
    2. HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
      Title: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
    3. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
      Title: Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
    4. results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling.
      Title: Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization.
    5. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
      Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
    6. Both Sstr3 (and SStr2) receptors are required for the anticonvulsant effects mediated by cortistatin-14.
      Title: Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.
    7. SSTR3 immunoreactivity increases in ApoD(-/-) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
      Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
    8. Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
      Title: Heteromerization of ciliary G protein-coupled receptors in the mouse brain.
    9. this novel finding that Rab21 regulates SSTR3 trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
      Title: Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3.
    10. somatostatin receptor 3 expression was restricted to the plasma membrane of cilia in insulin- and growth hormone-secreting cells of the mouse, differing from previously reported immunohistochemical localization in cell bodies
      Title: Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables somatostatin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in somatostatin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    somatostatin receptor type 3
    Names
    SS-3-R
    SS3-R
    SS3R
    SSR-28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356961.1 → NP_001343890.1  somatostatin receptor type 3

      Status: VALIDATED

      Source sequence(s)
      AL590144
      Consensus CDS
      CCDS27617.1
      UniProtKB/Swiss-Prot
      P30935, Q0VB04, Q3UVV5
      Conserved Domains (2) summary
      cd14964
      Location:48 → 72
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001411768.1 → NP_001398697.1  somatostatin receptor type 3

      Status: VALIDATED

      Source sequence(s)
      AL590144
      UniProtKB/Swiss-Prot
      P30935, Q0VB04, Q3UVV5

    3. NM_009218.3 → NP_033244.2  somatostatin receptor type 3

      See identical proteins and their annotated locations for NP_033244.2

      Status: VALIDATED

      Source sequence(s)
      AL590144
      Consensus CDS
      CCDS27617.1
      UniProtKB/Swiss-Prot
      P30935, Q0VB04, Q3UVV5
      Related
      ENSMUSP00000058040.3, ENSMUST00000053239.4
      Conserved Domains (2) summary
      cd14964
      Location:48 → 72
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78421214..78433565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245531.2 → XP_011243833.1  somatostatin receptor type 3 isoform X1

      See identical proteins and their annotated locations for XP_011243833.1

      UniProtKB/Swiss-Prot
      P30935, Q0VB04, Q3UVV5
      Conserved Domains (2) summary
      cd14964
      Location:48 → 72
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30935.2 GenPept UniProtKB/Swiss-Prot:P30935

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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