Npy2r neuropeptide Y receptor Y2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npy2rprovided by MGI
Official Full Name: neuropeptide Y receptor Y2provided by MGI
Primary source: MGI:MGI:108418
See related: Ensembl:ENSMUSG00000028004 AllianceGenome:MGI:108418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NPY2-R
Summary: Enables peptide YY receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is active in cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 1.5), genital fat pad adult (RPKM 1.1) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 36.49 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (82445688..82455404, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (82538383..82548989, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear.
Title: Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear.
Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.
Title: Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.
A role for NPY-NPY2R signaling in albuminuric kidney disease.
Title: A role for NPY-NPY2R signaling in albuminuric kidney disease.
Combined loss of GLP1R and Y2R-signaling was not able to negate or attenuate the beneficial effects of RYGB on body weight and glucose homeostasis in mice, suggesting that a larger number of signaling pathways is involved or that the critical pathway has not yet been identified.
Title: Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
It was concluded that PYY signaling through Y2R is not required for the normal appetite-suppressing and body weight-lowering effects of Roux-en-Y gastric bypass in this global knockout mouse model.
Title: The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery.
High Npy2r expression is associated with chronic social defeat stress.
Title: iTRAQ-based proteomics suggests LRP6, NPY and NPY2R perturbation in the hippocampus involved in CSDS may induce resilience and susceptibility.
These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. The effect on visceral pain seems to be mediated by peripheral Y2 receptors.
Title: Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism.
NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Title: Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
Findings suggest that neuropeptide Y is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
Title: Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.
confirms the critical role of Y2 signalling to control neuropeptide Y and associated pro-opiomelanocortin expression in the arcuate nuclei
Title: Y2 receptor signalling in NPY neurons controls bone formation and fasting induced feeding but not spontaneous feeding.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484953

PMC124402P1 (e-PCR)
- UniSTS:270468

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide Y receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide YY receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide YY receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nervous system process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide Y receptor type 2

Names: NPY-Y2 receptor; Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205099.2 → NP_001192028.1 neuropeptide Y receptor type 2 isoform 2

See identical proteins and their annotated locations for NP_001192028.1

Status: VALIDATED

Source sequence(s)

AC091478

Consensus CDS

CCDS57219.1

UniProtKB/TrEMBL

Q3SWR9

Related

ENSMUSP00000138559.2, ENSMUST00000182181.8

Conserved Domains (1) summary

pfam00001
Location:30 → 212

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001410443.1 → NP_001397372.1 neuropeptide Y receptor type 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC091478

UniProtKB/Swiss-Prot

F7C6W7, P97295, Q8BWV1

Related

ENSMUSP00000029633.5, ENSMUST00000029633.5
NM_001410444.1 → NP_001397373.1 neuropeptide Y receptor type 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC091478

UniProtKB/Swiss-Prot

F7C6W7, P97295, Q8BWV1

Related

ENSMUSP00000138282.2, ENSMUST00000182831.2
NM_001410445.1 → NP_001397374.1 neuropeptide Y receptor type 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC091478

UniProtKB/Swiss-Prot

F7C6W7, P97295, Q8BWV1
NM_008731.4 → NP_032757.2 neuropeptide Y receptor type 2 isoform 1

See identical proteins and their annotated locations for NP_032757.2

Status: VALIDATED

Source sequence(s)

AC091478

Consensus CDS

CCDS59646.1

UniProtKB/Swiss-Prot

F7C6W7, P97295, Q8BWV1

Related

ENSMUSP00000096595.5, ENSMUST00000098997.5

Conserved Domains (1) summary

cd15399
Location:51 → 336

7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors