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    plc-4 Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

    Gene ID: 177525, updated on 2-Nov-2024

    Summary

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    Official Symbol
    plc-4
    Official Full Name
    Phosphoinositide phospholipase C
    Primary source
    WormBase:WBGene00004039
    Locus tag
    CELE_R05G6.8
    See related
    AllianceGenome:WB:WBGene00004039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Is expressed in vas deferens. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3 and spermatogenic failure 17. Orthologous to several human genes including PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See plc-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (7509524..7512667, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Otopetrin-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative sodium-dependent excitatory amino acid transporter glt-6 Neighboring gene putative voltage-dependent anion-selective channel Neighboring gene Uroporphyrinogen-III synthase Neighboring gene ncRNA Neighboring gene Nitric oxide synthase-interacting protein homolog Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved gene targeting in C. elegans using counter-selection and Flp-mediated marker excision. Vázquez-Manrique RP, et al. Genomics, 2010 Jan. PMID 19747540
    2. Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans. Vázquez-Manrique RP, et al. PLoS Genet, 2008 Mar 28. PMID 18369461, Free PMC Article
    3. Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males. Gower NJ, et al. Mol Biol Cell, 2005 Sep. PMID 15958491, Free PMC Article
    4. IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans. Nagy AI, et al. EMBO Rep, 2015 Mar. PMID 25608529, Free PMC Article
    5. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphoinositide phospholipase C
    NP_501213.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7509524..7512667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068812.5 → NP_501213.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21754
      Conserved Domains (7) summary
      cd00275
      Location:621 → 748
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08558
      Location:315 → 596
      PI-PLCc_eukaryota; Catalytic domain of eukaryotic phosphoinositide-specific phospholipase C and similar proteins
      PLN02228
      Location:221 → 751
      PLN02228; Phosphoinositide phospholipase C
      pfam09279
      Location:231 → 315
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:161 → 223
      EF-hand_7; EF-hand domain pair
      pfam14788
      Location:176 → 226
      EF-hand_10; EF hand
      cl17171
      Location:29 → 145
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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