Frat1 frequently rearranged in advanced T cell lymphomas [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Frat1provided by MGI
Official Full Name: frequently rearranged in advanced T cell lymphomasprovided by MGI
Primary source: MGI:MGI:109450
See related: Ensembl:ENSMUSG00000067199 AllianceGenome:MGI:109450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable molecular function inhibitor activity. Acts upstream of or within embryonic axis specification and protein export from nucleus. Located in cytoplasm and nucleus. Is expressed in several structures, including bronchiole; central nervous system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human FRAT1 (FRAT regulator of WNT signaling pathway 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 35.3 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41818409..41821022)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41829970..41832583)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus.
Title: Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells.
Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
Title: Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
FRAT has a role in mediating GSK-3 nuclear export in mouse cells
Title: The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.
Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3.
Title: Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548355

NoName (e-PCR)
- UniSTS:548356

Frat1 (e-PCR), detects polymorphism
- UniSTS:143138

Frat1 (e-PCR), detects polymorphism
- UniSTS:532279

NoName (e-PCR)
- UniSTS:489053

NoName (e-PCR)
- UniSTS:495468

NoName (e-PCR)
- UniSTS:237939

Frat1 (e-PCR), detects polymorphism
- UniSTS:265596

AW060382 (e-PCR)
- UniSTS:181236

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene FRAT1

Names: frequently rearranged in advanced T-cell lymphomas 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.