MARCHF3 membrane associated ring-CH-type finger 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MARCHF3provided by HGNC
Official Full Name: membrane associated ring-CH-type finger 3provided by HGNC
Primary source: HGNC:HGNC:28728
See related: Ensembl:ENSG00000173926 MIM:613333; AllianceGenome:HGNC:28728
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MARCH3; RNF173; MARCH-III
Summary: This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
Expression: Broad expression in testis (RPKM 2.7), heart (RPKM 1.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q23.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (126867714..127030558, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (127387759..127550637, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (126203406..126366250, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma.
Title: RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma.
Report shows that silencing MARCH3 protects the endothelial barrier and upregulates OCLN in MARCH3-depleted cells. MARCH3 silencing results in the strengthening of cell-cell contacts and inactivates FoxO1.
Title: The E3 ubiquitin ligase MARCH3 controls the endothelial barrier.
LPS activation of TLR4 significantly increased MARCH3 expression and that siRNA against MARCH3 prevented the decrease in FcgammaRIIb following LPS treatment.
Title: Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-20738 (e-PCR)
- UniSTS:65031

RH16315 (e-PCR)
- UniSTS:26124

SGC35038 (e-PCR)
- UniSTS:26125

RH17775 (e-PCR)
- UniSTS:33834

RH47554 (e-PCR)
- UniSTS:55360

RH47138 (e-PCR)
- UniSTS:87130

SHGC-58339 (e-PCR)
- UniSTS:351

SHGC-58434 (e-PCR)
- UniSTS:94322

SHGC-58466 (e-PCR)
- UniSTS:94351

SHGC-57692 (e-PCR)
- UniSTS:53406

RH12395 (e-PCR)
- UniSTS:45258

SGC33891 (e-PCR)
- UniSTS:79841

SGC30895 (e-PCR)
- UniSTS:33784

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF3

Names: E3 ubiquitin-protein ligase MARCH3; RING finger protein 173; RING-type E3 ubiquitin transferase MARCH3; RING-type E3 ubiquitin transferase MARCHF3; membrane associated ring finger 3; membrane-associated RING-CH protein III; membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase

NP_848545.1

EC 2.3.2.27

XP_011541433.1

EC 2.3.2.27

XP_016864504.1

EC 2.3.2.27

XP_054207529.1

EC 2.3.2.27

XP_054207530.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033192.1 RefSeqGene

Range

5251..168095

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_178450.5 → NP_848545.1 E3 ubiquitin-protein ligase MARCHF3

See identical proteins and their annotated locations for NP_848545.1

Status: REVIEWED

Source sequence(s)

AC093532, AC137794, BC047569, DB455278

Consensus CDS

CCDS4141.1

UniProtKB/Swiss-Prot

A8K264, B9EJE7, Q86UD3

Related

ENSP00000309141.5, ENST00000308660.6

Conserved Domains (1) summary

cd16699
Location:70 → 120

RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

126867714..127030558 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011543131.4 → XP_011541433.1 E3 ubiquitin-protein ligase MARCHF3 isoform X1

See identical proteins and their annotated locations for XP_011541433.1

Conserved Domains (1) summary

smart00744
Location:70 → 117

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
XM_017009015.2 → XP_016864504.1 E3 ubiquitin-protein ligase MARCHF3 isoform X2