U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FERMT2 FERM domain containing kindlin 2 [ Homo sapiens (human) ]

    Gene ID: 10979, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FERMT2provided by HGNC
    Official Full Name
    FERM domain containing kindlin 2provided by HGNC
    Primary source
    HGNC:HGNC:15767
    See related
    Ensembl:ENSG00000073712 MIM:607746; AllianceGenome:HGNC:15767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B
    Summary
    Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and positive regulation of intracellular signal transduction. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in several cellular components, including adherens junction; cytoplasmic side of plasma membrane; and focal adhesion. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 84.8), endometrium (RPKM 56.1) and 22 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FERMT2 in Genome Data Viewer
    Location:
    14q22.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (52857273..52951050, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (47065165..47158990, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53323991..53417768, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8397 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr14:53257919-53258432 and GRCh37_chr14:53258433-53258947 Neighboring gene uncharacterized LOC105370500 Neighboring gene COP9 signalosome subunit 9 pseudogene Neighboring gene glucosamine-phosphate N-acetyltransferase 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53301633-53302238 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53302239-53302843 Neighboring gene Sharpr-MPRA regulatory region 8176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53350617-53351142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:53351143-53351668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8398 Neighboring gene Sharpr-MPRA regulatory region 10339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5751 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:53418467-53419045 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 3 Neighboring gene DDHD domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5752

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of the human kindlin-2 PH domain. Lee JH, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jun 1. PMID 21636915, Free PMC Article
    2. Kindlin-2 promoted the progression of keloids through the Smad pathway and Fas/FasL pathway. Huang S, et al. Exp Cell Res, 2021 Nov 1. PMID 34492266
    3. Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion. Kawamura E, et al. BMC Dev Biol, 2018 Nov 1. PMID 30382829, Free PMC Article
    4. Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma. Mahawithitwong P, et al. Pancreas, 2013 May. PMID 23508013
    5. Kindlin-2 expression in adult tissues correlates with their embryonic origins. Zhan J, et al. Sci China Life Sci, 2014 Jul. PMID 24907935

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-alpha-Pix to Rac1 to activate the MAPK pathway.
      Title: Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway.
    2. FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.
      Title: FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.
    3. Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/beta-catenin mediated pathway.
      Title: Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/β-catenin mediated pathway.
    4. Kindlin-2 controls angiogenesis through modulating Notch1 signaling.
      Title: Kindlin-2 controls angiogenesis through modulating Notch1 signaling.
    5. Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
      Title: Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
    6. Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/beta-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer.
      Title: Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer.
    7. Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.
      Title: Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.
    8. Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System.
      Title: Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System.
    9. YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2.
      Title: YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2.
    10. Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
      Title: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
    Submit: New GeneRIF Correction See all GeneRIFs (70)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog
    Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ34213, FLJ44462, DKFZp686G11125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables type I transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in limb development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of integrin activation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mesenchymal stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of wound healing, spreading of epidermal cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    fermitin family homolog 2
    Names
    PH domain-containing family C member 1
    fermitin family member 2
    kindlin 2
    mitogen inducible gene 2 protein
    mitogen inducible gene-2
    pleckstrin homology domain containing, family C (with FERM domain) member 1
    pleckstrin homology domain containing, family C member 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134999.2 → NP_001128471.1  fermitin family homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001128471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to variant 1, resulting in a longer isoform (2) with an internal 7 aa segment missing in isoform 1.
      Source sequence(s)
      AL139317, BC011125, BC017327, BX161467
      Consensus CDS
      CCDS45107.1
      UniProtKB/TrEMBL
      A8K6S3
      Related
      ENSP00000342858.4, ENST00000343279.8
      Conserved Domains (6) summary
      smart00295
      Location:241 → 324
      B41; Band 4.1 homologues
      cd01237
      Location:373 → 497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:574 → 665
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      cd17181
      Location:17 → 96
      FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)
      cd17184
      Location:97 → 277
      FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)
      pfam00373
      Location:504 → 580
      FERM_M; FERM central domain

    2. NM_001135000.2 → NP_001128472.1  fermitin family homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001128472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an additional in-frame coding exon and is missing the 3' terminal exon compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus and an internal 7 aa segment missing in isoform 1.
      Source sequence(s)
      AL139317, BC017327, BX161467
      Consensus CDS
      CCDS45108.1
      UniProtKB/TrEMBL
      A8K6S3
      Related
      ENSP00000382243.3, ENST00000399304.7
      Conserved Domains (4) summary
      smart00295
      Location:241 → 324
      B41; Band 4.1 homologues
      cd01237
      Location:373 → 497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:509 → 580
      FERM_M; FERM central domain
      cl17171
      Location:574 → 631
      PH-like; Pleckstrin homology-like domain

    3. NM_006832.3 → NP_006823.1  fermitin family homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_006823.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AL139317, BC011125, BC017327, BX161467
      Consensus CDS
      CCDS9713.1
      UniProtKB/Swiss-Prot
      B5TJY2, Q14840, Q86TY7, Q96AC1
      UniProtKB/TrEMBL
      A8K6S3
      Related
      ENSP00000340391.3, ENST00000341590.8
      Conserved Domains (6) summary
      smart00295
      Location:241 → 324
      B41; Band 4.1 homologues
      cd01237
      Location:373 → 497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:567 → 658
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      cd17181
      Location:17 → 96
      FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)
      cd17184
      Location:97 → 277
      FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)
      pfam00373
      Location:504 → 573
      FERM_M; FERM central domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      52857273..52951050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720010.4 → XP_006720073.1  fermitin family homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_006720073.1

      UniProtKB/TrEMBL
      A8K6S3
      Conserved Domains (5) summary
      cd01237
      Location:373 → 497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:582 → 673
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00169
      Location:381 → 476
      PH; PH domain
      pfam00373
      Location:509 → 588
      FERM_M; FERM central domain
      cl09511
      Location:283 → 326
      FERM_B-lobe; FERM domain B-lobe

    2. XM_005267285.4 → XP_005267342.1  fermitin family homolog 2 isoform X4

      See identical proteins and their annotated locations for XP_005267342.1

      UniProtKB/TrEMBL
      A8K6S3
      Conserved Domains (6) summary
      smart00295
      Location:252 → 335
      B41; Band 4.1 homologues
      cd01237
      Location:384 → 508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:578 → 669
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      cd17181
      Location:17 → 96
      FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)
      cd17184
      Location:97 → 288
      FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)
      pfam00373
      Location:533 → 584
      FERM_M; FERM central domain

    3. XM_006720009.4 → XP_006720072.1  fermitin family homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_006720072.1

      UniProtKB/TrEMBL
      A8K6S3
      Related
      ENSP00000450741.1, ENST00000554152.5
      Conserved Domains (6) summary
      smart00295
      Location:252 → 335
      B41; Band 4.1 homologues
      cd01237
      Location:384 → 508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:585 → 676
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      cd17181
      Location:17 → 96
      FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)
      cd17184
      Location:97 → 288
      FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)
      pfam00373
      Location:521 → 591
      FERM_M; FERM central domain

    4. XM_006720008.4 → XP_006720071.1  fermitin family homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006720071.1

      UniProtKB/TrEMBL
      A8K6S3
      Conserved Domains (5) summary
      cd01237
      Location:384 → 508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:593 → 684
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00169
      Location:392 → 487
      PH; PH domain
      pfam00373
      Location:520 → 599
      FERM_M; FERM central domain
      cl09511
      Location:294 → 337
      FERM_B-lobe; FERM domain B-lobe

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      47065165..47158990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375284.1 → XP_054231259.1  fermitin family homolog 2 isoform X3

    2. XM_054375285.1 → XP_054231260.1  fermitin family homolog 2 isoform X4

    3. XM_054375283.1 → XP_054231258.1  fermitin family homolog 2 isoform X2

    4. XM_054375282.1 → XP_054231257.1  fermitin family homolog 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96AC1.1 GenPept UniProtKB/Swiss-Prot:Q96AC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous