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    strc1 stereocilin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 101886410, updated on 2-Nov-2024

    Summary

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    Official Symbol
    strc1provided by ZNC
    Official Full Name
    stereocilin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110411-215
    See related
    Ensembl:ENSDARG00000079336 AllianceGenome:ZFIN:ZDB-GENE-110411-215
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-150j10.4
    Summary
    Predicted to be involved in cell-matrix adhesion. Predicted to be located in membrane. Predicted to be active in cell surface; kinocilium; and stereocilium tip. Is expressed in neuromast. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 16 and sensorineural hearing loss. Orthologous to human STRC (stereocilin) and STRCP1 (stereocilin pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See strc1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (31395465..31425899)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (31124495..31154307)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene golgi membrane protein 2 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2b Neighboring gene eukaryotic translation initiation factor 3, subunit Jb Neighboring gene cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish. Erickson T, et al. BMC Genomics, 2015 Oct 23. PMID 26494580, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinocilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in stereocilium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stereocilin; stereocilin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      31395465..31425899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168943.5 → XP_005169000.2  stereocilin

      UniProtKB/TrEMBL
      A0A2R8PYF0, A0A8M2BGU4
      Related
      ENSDARP00000146049.1, ENSDART00000182166.1
      Conserved Domains (1) summary
      pfam06060
      Location:1714 → 1911
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
    Nucleotide Protein Strain
    Heading Accession and Version

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