SELENOM selenoprotein M [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: SELENOMprovided by CGNC
Official Full Name: selenoprotein Mprovided by CGNC
Primary source: CGNC:66732
See related: Ensembl:ENSGALG00010022084
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SELM
Summary: The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known, but it may have a role in maintaining redox homeostasis. It is localized in the perinuclear region, and is highly expressed in the brain in mammals. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (9996286..9998317, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (9995647..9997706, complement)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-138-5p is involved in the mitochondrial apoptosis pathway via targeting SelM in chicken chondrocytes.
Title: The regulatory effects of miR-138-5p on selenium deficiency-induced chondrocyte apoptosis are mediated by targeting SelM.
results demonstrated that SelM may have an important role in protecting against oxidative damage in the brain of chicken, which might shed light on the role of SelM in human neurodegenerative disease
Title: Characterization of Selenoprotein M and Its Response to Selenium Deficiency in Chicken Brain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: selenoprotein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277859.2 → NP_001264788.1 selenoprotein M precursor

Status: REVIEWED

Source sequence(s)

BU291967, BU304002, BU320012, BU370564, JAENSK010000260

UniProtKB/TrEMBL

A0A8V0ZNE9

Related

ENSGALP00010032346.1, ENSGALT00010053703.1

Conserved Domains (1) summary

pfam08806
Location:29 → 103

Sep15_SelM; Sep15/SelM redox domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

9996286..9998317 complement

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GenBank, FASTA, Sequence Viewer (Graphics)