Alkal2 ALK and LTK ligand 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alkal2provided by MGI
Official Full Name: ALK and LTK ligand 2provided by MGI
Primary source: MGI:MGI:3697448
See related: Ensembl:ENSMUSG00000054204 AllianceGenome:MGI:3697448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam150b; Augalpha; 6230419C23Rik
Summary: Predicted to enable receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. Orthologous to human ALKAL2 (ALK and LTK ligand 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 1.2), limb E14.5 (RPKM 0.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 13.0 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (30934323..30943855)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (30884324..30893856)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A hypothalamic pathway for Augmentor alpha-controlled body weight regulation.
Title: A hypothalamic pathway for Augmentor α-controlled body weight regulation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor signaling protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK5 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK5 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK5 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ALK and LTK ligand 2

Names: Augmentor alpha; Protein FAM150B; family with sequence similarity 150, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159743.2 → NP_001153215.1 ALK and LTK ligand 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001153215.1

Status: VALIDATED

Source sequence(s)

AC160932

Consensus CDS

CCDS49044.1

UniProtKB/Swiss-Prot

G3X9F3, Q80UG6

Related

ENSMUSP00000070037.7, ENSMUST00000067087.7

Conserved Domains (1) summary

pfam15129
Location:32 → 150

FAM150; FAM150 family
NM_001377064.1 → NP_001363993.1 ALK and LTK ligand 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC160932

Conserved Domains (1) summary

pfam15129
Location:32 → 132

FAM150; FAM150 family