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    ncoa6 nuclear receptor coactivator 6 [ Danio rerio (zebrafish) ]

    Gene ID: 100144559, updated on 12-Sep-2024

    Summary

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    Official Symbol
    ncoa6provided by ZNC
    Official Full Name
    nuclear receptor coactivator 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080403-12
    See related
    Ensembl:ENSDARG00000071272 AllianceGenome:ZFIN:ZDB-GENE-080403-12
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb25d11; gb:dq017635
    Summary
    Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex and transcription regulator complex. Is expressed in embryonic structure. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ncoa6 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (2703174..2725407)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (2761485..2783731)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene gamma-glutamyltransferase 7 Neighboring gene protein diaphanous homolog 1 Neighboring gene zgc:114123 Neighboring gene DNA topoisomerase Ib

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345
    2. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
    3. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      2703174..2725407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170565.5 → XP_005170622.1  nuclear receptor coactivator 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHX6, F1R869
      Related
      ENSDARP00000096057.4, ENSDART00000105286.5
      Conserved Domains (2) summary
      pfam09606
      Location:130 → 536
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:38 → 180
      Nucleic_acid_bd; Putative nucleic acid-binding region

    2. XM_005170566.5 → XP_005170623.1  nuclear receptor coactivator 6 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BHW9
      Related
      ENSDARP00000153734.1, ENSDART00000182512.1
      Conserved Domains (2) summary
      pfam09606
      Location:130 → 536
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:38 → 180
      Nucleic_acid_bd; Putative nucleic acid-binding region

    3. XM_001918962.8 → XP_001918997.4  nuclear receptor coactivator 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M1QK83
      Conserved Domains (1) summary
      pfam13820
      Location:38 → 180
      Nucleic_acid_bd; Putative nucleic acid-binding region
    Nucleotide Protein Strain
    Heading Accession and Version

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