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    dgka diacylglycerol kinase alpha [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100124931, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dgkaprovided by Xenbase
    Official Full Name
    diacylglycerol kinase alphaprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-985269
    See related
    Ensembl:ENSXETG00000009437
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    dagk; dagk1; dgk-alpha
    Orthologs
    human mouse all
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    Genomic context

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    See dgka in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (137911709..137993905, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (134648010..134733216, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 2 Neighboring gene premelanosome protein Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene growth differentiation factor 11, gene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    diacylglycerol kinase, alpha 80kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      137911709..137993905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012957810.3 → XP_012813264.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813264.1

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    2. XM_012957812.3 → XP_012813266.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813266.1

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    3. XM_012957811.3 → XP_012813265.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813265.1

      UniProtKB/TrEMBL
      F7DBT3
      Related
      ENSXETP00000020793.5, ENSXETT00000020793.5
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    4. XM_012957813.3 → XP_012813267.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813267.1

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    5. XM_018091693.2 → XP_017947182.1  diacylglycerol kinase alpha

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    6. XM_012957808.3 → XP_012813262.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813262.1

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    7. XM_012957809.3 → XP_012813263.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813263.1

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    8. XM_031897165.1 → XP_031753025.1  diacylglycerol kinase alpha

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins

    9. XM_012957814.3 → XP_012813268.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for XP_012813268.1

      UniProtKB/TrEMBL
      F7DBT3
      Conserved Domains (6) summary
      smart00045
      Location:532 → 711
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:126 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:7 → 122
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20799
      Location:213 → 274
      C1_DGK_typeI_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases
      cd20890
      Location:283 → 342
      C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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