Alyreffm4 Aly/REF export factor family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alyreffm4provided by MGI
Official Full Name: Aly/REF export factor family member 4provided by MGI
Primary source: MGI:MGI:3782481
See related: Ensembl:ENSMUSG00000094314 AllianceGenome:MGI:3782481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm4301
Summary: Predicted to enable C5-methylcytidine-containing RNA reader activity and mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of catalytic step 2 spliceosome; exon-exon junction complex; and transcription export complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Orthologous to human ALYREF (Aly/REF export factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 10 D1; 10 51.45 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (100171538..100172451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (100335676..100336589)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C5-methylcytidine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uncharacterized protein LOC100043224

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166637.1 → NP_001160109.1 uncharacterized protein LOC100043224

See identical proteins and their annotated locations for NP_001160109.1

Status: VALIDATED

Source sequence(s)

AC164629

Consensus CDS

CCDS88077.1

UniProtKB/TrEMBL

K9J7E2

Related

ENSMUSP00000140999.4, ENSMUST00000186197.5

Conserved Domains (3) summary

COG0724
Location:79 → 195

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12680
Location:86 → 160

RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins

pfam07078
Location:6 → 59

FYTT; Forty-two-three protein