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    dre-mir-103 microRNA 103 [ Danio rerio (zebrafish) ]

    Gene ID: 100033625, updated on 28-Oct-2024

    Summary

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    Official Symbol
    dre-mir-103provided by ZNC
    Official Full Name
    microRNA 103provided by ZNC
    Primary source
    ZFIN:ZDB-MIRNAG-081203-11
    See related
    Ensembl:ENSDARG00000081583 miRBase:MI0001962; AllianceGenome:ZFIN:ZDB-MIRNAG-081203-11
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mir103
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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    Genomic context

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    See dre-mir-103 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15223296..15223383)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15092304..15092391)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000801 Neighboring gene mitochondrial antiviral signaling protein Neighboring gene pantothenate kinase 2 Neighboring gene lysyl oxidase-like 3b Neighboring gene uncharacterized LOC137487379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. Ohno M, et al. Sci Rep, 2013. PMID 23989853, Free PMC Article
    2. miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis. Heigwer J, et al. Biochem Biophys Res Commun, 2020 Jun 25. PMID 32334837
    3. The evolution of evolvability in microRNA target sites in vertebrates. Xu J, et al. Genome Res, 2013 Nov. PMID 24077390, Free PMC Article
    4. MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Kapsimali M, et al. Genome Biol, 2007. PMID 17711588, Free PMC Article
    5. Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs. Nepal C, et al. Nucleic Acids Res, 2016 Apr 20. PMID 26673698, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis.
      Title: miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis.
    2. These results suggest that apigenin may have favorable effects on the pathogenic status induced by overexpression of miRNA103, whose maturation is mediated by phosphorylated TRBP
      Title: The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.
    Submit: New GeneRIF Correction

    General gene information

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    Other Names

    • miR-103
    • mirn103

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in Kupffer's vesicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_030056.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      BX323842
      Related
      ENSDART00000116601.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      15223296..15223383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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