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    cadpsb Ca2+-dependent activator protein for secretion b [ Danio rerio (zebrafish) ]

    Gene ID: 100001129, updated on 17-Sep-2024

    Summary

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    Official Symbol
    cadpsbprovided by ZNC
    Official Full Name
    Ca2+-dependent activator protein for secretion bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110621-2
    See related
    Ensembl:ENSDARG00000070567 AllianceGenome:ZFIN:ZDB-GENE-110621-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to act upstream of or within dense core granule exocytosis; protein transport; and synaptic vesicle exocytosis. Predicted to be located in cytoplasmic vesicle. Predicted to be active in glutamatergic synapse. Orthologous to human CADPS (calcium dependent secretion activator). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See cadpsb in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (41255401..41445563)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (41257797..41448029)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene synaptoporin b Neighboring gene uncharacterized LOC137495887 Neighboring gene uncharacterized LOC100536148 Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene microRNA let7j Neighboring gene WD repeat domain 82

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of A-to-I RNA editing in zebrafish development and adult organs. Buchumenski I, et al. Nucleic Acids Res, 2021 May 7. PMID 33872356, Free PMC Article
    2. Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. Moravec CE, et al. J Neurosci, 2016 Sep 7. PMID 27605615, Free PMC Article
    3. Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Ogawa Y, et al. Proc Biol Sci, 2015 Aug 7. PMID 26180064, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium-dependent secretion activator 1
    Names
    Ca2+-dependent secretion activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      41255401..41445563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222029.1 → XP_068078130.1  calcium-dependent secretion activator 1 isoform X1

    2. XM_068222035.1 → XP_068078136.1  calcium-dependent secretion activator 1 isoform X8

    3. XM_068222030.1 → XP_068078131.1  calcium-dependent secretion activator 1 isoform X2

    4. XM_068222036.1 → XP_068078137.1  calcium-dependent secretion activator 1 isoform X9

    5. XM_068222031.1 → XP_068078132.1  calcium-dependent secretion activator 1 isoform X3

    6. XM_068222032.1 → XP_068078133.1  calcium-dependent secretion activator 1 isoform X4

    7. XM_068222033.1 → XP_068078134.1  calcium-dependent secretion activator 1 isoform X5

    8. XM_005166114.5 → XP_005166171.1  calcium-dependent secretion activator 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M2BDG8
      Conserved Domains (4) summary
      smart00239
      Location:364 → 447
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:480 → 599
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:490 → 587
      PH; PH domain
      pfam06292
      Location:801 → 915
      DUF1041; Domain of Unknown Function (DUF1041)

    9. XM_003198809.6 → XP_003198857.1  calcium-dependent secretion activator 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M1RM00
      Conserved Domains (4) summary
      smart00239
      Location:364 → 447
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:480 → 599
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:490 → 587
      PH; PH domain
      pfam06292
      Location:801 → 915
      DUF1041; Domain of Unknown Function (DUF1041)

    10. XM_068222034.1 → XP_068078135.1  calcium-dependent secretion activator 1 isoform X7

      Related
      ENSDARP00000042682.6, ENSDART00000042683.8

    11. XM_021477245.2 → XP_021332920.1  calcium-dependent secretion activator 1 isoform X11

      UniProtKB/TrEMBL
      A0A8M9QGB4
      Conserved Domains (3) summary
      smart00239
      Location:364 → 447
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:480 → 599
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:801 → 903
      DUF1041; Domain of Unknown Function (DUF1041)
    Nucleotide Protein
    Heading Accession and Version

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