SYTL1 synaptotagmin like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SYTL1provided by HGNC
Official Full Name: synaptotagmin like 1provided by HGNC
Primary source: HGNC:HGNC:15584
See related: Ensembl:ENSG00000142765 MIM:608042; AllianceGenome:HGNC:15584
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JFC1; SLP1
Summary: Predicted to enable neurexin family protein binding activity. Involved in exocytosis. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in prostate (RPKM 24.6), skin (RPKM 21.7) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (27342022..27353932)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (27183258..27195171)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (27668513..27680423)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.
Title: WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.
ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.
Title: ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.
results reveal that MEIS1, through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma.
Title: MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.
Cdk2 also binds the N-terminal domain of Fbw7-gamma as well as SLP-1.
Title: The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.
during exocytosis, actin depolymerization commences near the secretory organelle, not the plasma membrane, and secretory granules use a JFC1- and GMIP-dependent molecular mechanism to traverse cortical actin.
Title: Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 modulates secretion by binding to Slp1.
Title: Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.
These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
Title: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
transcriptional activation of JFC1 by the TNFalpha/NF-kappaB pathway is significant in prostate carcinoma cell lines
Title: JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells.
evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers
Title: The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.
Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-156284 (e-PCR)
- UniSTS:182124

SHGC-74508 (e-PCR)
- UniSTS:70533

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurexin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in melanosome	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: synaptotagmin-like protein 1

Names: NADPH oxidase-related, C2 domain-containing protein; exophilin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193308.2 → NP_001180237.1 synaptotagmin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001180237.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

BC035725, DA948740

Consensus CDS

CCDS53286.1

UniProtKB/Swiss-Prot

Q5SSC9, Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0

UniProtKB/TrEMBL

A8KAH3

Related

ENSP00000481032.1, ENST00000616558.5

Conserved Domains (3) summary

cd04020
Location:399 → 555

C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4

cd08393
Location:267 → 386

C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2

cl22851
Location:35 → 99

PHD_SF; PHD finger superfamily
NM_032872.3 → NP_116261.1 synaptotagmin-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_116261.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK027902, CB851688

Consensus CDS

CCDS298.1

UniProtKB/TrEMBL

A8KAH3

Related

ENSP00000316464.5, ENST00000318074.9

Conserved Domains (3) summary

cd04020
Location:387 → 543

C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4

cd08393
Location:255 → 374

C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2

cl22851
Location:35 → 99

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

27342022..27353932

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005246022.4 → XP_005246079.1 synaptotagmin-like protein 1 isoform X1

UniProtKB/TrEMBL

A8KAH3

Related

ENST00000483926.5

Conserved Domains (3) summary

cd04020
Location:431 → 587

C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4

cd08393
Location:299 → 418

C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2

cl22851
Location:67 → 131

PHD_SF; PHD finger superfamily
XM_006710990.2 → XP_006711053.1 synaptotagmin-like protein 1 isoform X2

UniProtKB/TrEMBL

A8KAH3

Conserved Domains (3) summary

cd04020
Location:419 → 575

C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4

cd08393
Location:287 → 406

C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2

cl22851
Location:67 → 131

PHD_SF; PHD finger superfamily
XM_047432563.1 → XP_047288519.1 synaptotagmin-like protein 1 isoform X3
XM_047432574.1 → XP_047288530.1 synaptotagmin-like protein 1 isoform X4
XM_047432582.1 → XP_047288538.1 synaptotagmin-like protein 1 isoform X5