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    SRSF7 serine and arginine rich splicing factor 7 [ Homo sapiens (human) ]

    Gene ID: 6432, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SRSF7provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 7provided by HGNC
    Primary source
    HGNC:HGNC:10789
    See related
    Ensembl:ENSG00000115875 MIM:600572; AllianceGenome:HGNC:10789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    9G8; AAG3; SFRS7
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]
    Expression
    Ubiquitous expression in bone marrow (RPKM 57.8), lymph node (RPKM 43.5) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See SRSF7 in Genome Data Viewer
    Location:
    2p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38743599..38751494, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (38752384..38760281, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38970741..38978636, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11378 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1526 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:38893008-38893520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:38893521-38894033 Neighboring gene uncharacterized LOC124905993 Neighboring gene galactose mutarotase Neighboring gene Sharpr-MPRA regulatory region 4561 Neighboring gene MPRA-validated peak3666 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15609 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:38967980-38968152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15610 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:38982351-38983102 Neighboring gene tetratricopeptide repeat domain 39D, pseudogene Neighboring gene NPL pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts. Popielarz M, et al. J Biol Chem, 1995 Jul 28. PMID 7629084
    2. SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Gao L, et al. Mol Cell Neurosci, 2007 Jan. PMID 17137791, Free PMC Article
    3. The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. Swartz JE, et al. J Biol Chem, 2007 Jul 6. PMID 17513303
    4. Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma. Cun Y, et al. Genomics Proteomics Bioinformatics, 2023 Aug. PMID 34954129, Free PMC Article
    5. Alternative splicing of intron 3 of the serine/arginine-rich protein 9G8 gene. Identification of flanking exonic splicing enhancers and involvement of 9G8 as a trans-acting factor. Lejeune F, et al. J Biol Chem, 2001 Mar 16. PMID 11096110

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRSF7 downregulation induces cellular senescence through generation of MDM2 variants.
      Title: SRSF7 downregulation induces cellular senescence through generation of MDM2 variants.
    2. Specific Regulation of m[6]A by SRSF7 Promotes the Progression of Glioblastoma.
      Title: Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
    3. The splicing factor 9G8 regulates the expression of NADPH-producing enzyme genes in Drosophila.
      Title: The splicing factor 9G8 regulates the expression of NADPH-producing enzyme genes in Drosophila.
    4. Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
      Title: Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
    5. Long non-coding RNA MALAT1 regulates proliferation, apoptosis, migration and invasion via miR-374b-5p/SRSF7 axis in non-small cell lung cancer.
      Title: Long non-coding RNA MALAT1 regulates proliferation, apoptosis, migration and invasion via miR-374b-5p/SRSF7 axis in non-small cell lung cancer.
    6. role of SRSF7 in cell proliferation through regulating p21 levels.
      Title: Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells.
    7. SRSF7 expression in cancer cells is regulated by microRNAs: short, non-coding RNAs that bind to 3'UTR of target genes and downregulate their expression. SRSF7 regulate proliferation of renal cancer cells.SRSF7 regulates expression of osteopontin.
      Title: microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells.
    8. Genome-wide identification of CD95 antigen alternative splicing regulators, such as SRSF7, reveals links with iron homeostasis.
      Title: Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis.
    9. Coexpression of Dyrk1A and splicing factor 9G8 leads to their translocation from the nucleus to the cytoplasm and suppresses their ability to regulate tau exon 10 splicing.
      Title: Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A.
    10. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10
      Title: Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 7 (SRSF7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 7 (SRSF7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 7 (SRSF7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 7 (SRSF7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat SRSF7 (serine/arginine-rich splicing factor 7) inhibits HIV-1 Tat-mediated transactivation activity in HEK293 cells PubMed
    tat HIV-1 Tat synergizes with type I activators, such as Sp1 and CTF, to enhance transcript elongation and exon skipping, suggesting Tat function leads to the inhibition of splicing factors SF2/ASF and 9G8 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 7
    Names
    SR splicing factor 7
    aging-associated protein 3
    splicing factor 9G8
    splicing factor, arginine/serine-rich 7, 35kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031684.3 → NP_001026854.1  serine/arginine-rich splicing factor 7 isoform 1

      See identical proteins and their annotated locations for NP_001026854.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC074366, AY166860
      Consensus CDS
      CCDS33183.1
      UniProtKB/Swiss-Prot
      B4DLU6, G5E9M3, Q16629, Q564D3
      Related
      ENSP00000325905.6, ENST00000313117.11
      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    2. NM_001195446.2 → NP_001182375.1  serine/arginine-rich splicing factor 7 isoform 2

      See identical proteins and their annotated locations for NP_001182375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC074366, AK297161, AY166860
      Consensus CDS
      CCDS56115.1
      UniProtKB/Swiss-Prot
      Q16629
      Related
      ENSP00000402264.2, ENST00000446327.6
      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    3. NM_001363802.1 → NP_001350731.1  serine/arginine-rich splicing factor 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC074366
      Consensus CDS
      CCDS86832.1
      UniProtKB/TrEMBL
      C9JAB2
      Related
      ENSP00000386806.1, ENST00000409276.5
      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      38743599..38751494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264485.3 → XP_005264542.1  serine/arginine-rich splicing factor 7 isoform X1

      See identical proteins and their annotated locations for XP_005264542.1

      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    2. XM_011533032.3 → XP_011531334.1  serine/arginine-rich splicing factor 7 isoform X2

      See identical proteins and their annotated locations for XP_011531334.1

    RNA

    1. XR_007079572.1 RNA Sequence

    2. XR_007079573.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      38752384..38760281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343365.1 → XP_054199340.1  serine/arginine-rich splicing factor 7 isoform X1

    2. XM_054343366.1 → XP_054199341.1  serine/arginine-rich splicing factor 7 isoform X2

    RNA

    1. XR_008486488.1 RNA Sequence

    2. XR_008486487.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_006276.36: Suppressed sequence

      Description
      NM_006276.36: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16629.1 GenPept UniProtKB/Swiss-Prot:Q16629

    Gene LinkOut

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