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    ILK integrin linked kinase [ Homo sapiens (human) ]

    Gene ID: 3611, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ILKprovided by HGNC
    Official Full Name
    integrin linked kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6040
    See related
    Ensembl:ENSG00000166333 MIM:602366; AllianceGenome:HGNC:6040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P59; ILK-1; ILK-2; p59ILK; HEL-S-28
    Summary
    This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ILK in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6603774..6610870)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6662246..6669338)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6625004..6632101)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene dynein heavy chain domain 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6589123-6589980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6592335-6592842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6607422-6608410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6608411-6609399 Neighboring gene Sharpr-MPRA regulatory region 2811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6624079-6624620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4347 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6632062-6632650 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6632651-6633238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3106 Neighboring gene ribosomal RNA processing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4350 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4352 Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6662561-6663130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6668387-6668887

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Qu Y, et al. Mol Med Rep, 2017 Oct. PMID 28791358
    2. Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. Wang F, et al. J Cell Biochem, 2011 Nov. PMID 21688303
    3. Integrin-linked kinase: not so 'pseudo' after all. Hannigan GE, et al. Oncogene, 2011 Oct 27. PMID 21602880
    4. Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells. Gao J, et al. Int J Biochem Cell Biol, 2011 Sep. PMID 21601006
    5. Inhibition of high glucose-induced VEGF and ICAM-1 expression in human retinal pigment epithelium cells by targeting ILK with small interference RNA. Wang W, et al. Mol Biol Rep, 2012 Jan. PMID 21553049

    See all (377) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.
      Title: Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.
    2. Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease.
      Title: Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease.
    3. Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
      Title: Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
    4. Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
      Title: Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
    5. Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
      Title: Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
    6. The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
      Title: The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
    7. Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
      Title: Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
    8. Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
      Title: Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
    9. Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
      Title: Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
    10. Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
      Title: Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (244)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686F1765

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in caveola assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myelination in peripheral nervous system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet aggregation HMP PubMed 
    involved_in positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrin-linked protein kinase
    Names
    59 kDa serine/threonine-protein kinase
    beta-integrin-linked kinase
    epididymis secretory protein Li 28
    integrin-linked kinase-2
    NP_001014794.1
    NP_001014795.1
    NP_001265370.1
    NP_001265371.1
    NP_004508.1
    XP_005252961.1
    XP_011518367.1
    XP_024304266.1
    XP_024304267.1
    XP_047282841.1
    XP_054224646.1
    XP_054224647.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029702.1 RefSeqGene

      Range
      4975..12142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

    mRNA and Protein(s)

    1. NM_001014794.3 → NP_001014794.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001014794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      BC001554, DC380243, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
      UniProtKB/TrEMBL
      A0A0A0MTH3, V9HWF0
      Related
      ENSP00000403487.2, ENST00000420936.6
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001014795.3 → NP_001014795.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001014795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AC091564, CR749220, DC379936, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
      UniProtKB/TrEMBL
      A0A0A0MTH3, V9HWF0
      Related
      ENSP00000379975.2, ENST00000396751.6
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001278441.2 → NP_001265370.1  integrin-linked protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001265370.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC091564, AK296628, DC380243, HY257434, U40282
      Consensus CDS
      CCDS60712.1
      UniProtKB/TrEMBL
      A0A0A0MTH3
      Related
      ENSP00000435323.1, ENST00000528995.5
      Conserved Domains (4) summary
      cd14057
      Location:144 → 388
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 117
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001278442.2 → NP_001265371.1  integrin-linked protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001265371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK293474
      Consensus CDS
      CCDS60713.1
      UniProtKB/Swiss-Prot
      Q13418
      Related
      ENSP00000434492.2, ENST00000532063.5
      Conserved Domains (1) summary
      cd14057
      Location:63 → 315
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase

    5. NM_004517.4 → NP_004508.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_004508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      DC380243, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
      UniProtKB/TrEMBL
      A0A0A0MTH3, V9HWF0
      Related
      ENSP00000299421.4, ENST00000299421.9
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6603774..6610870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520065.2 → XP_011518367.1  integrin-linked protein kinase isoform X1

      See identical proteins and their annotated locations for XP_011518367.1

      UniProtKB/Swiss-Prot
      B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
      UniProtKB/TrEMBL
      A0A0A0MTH3, V9HWF0
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_047426885.1 → XP_047282841.1  integrin-linked protein kinase isoform X3

    3. XM_005252904.6 → XP_005252961.1  integrin-linked protein kinase isoform X1

      See identical proteins and their annotated locations for XP_005252961.1

      UniProtKB/Swiss-Prot
      B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
      UniProtKB/TrEMBL
      A0A0A0MTH3, V9HWF0
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_024448499.2 → XP_024304267.1  integrin-linked protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0A0MTH3
      Conserved Domains (3) summary
      cd14057
      Location:146 → 398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:15 → 46
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 73
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_024448498.2 → XP_024304266.1  integrin-linked protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0A0MTH3
      Conserved Domains (3) summary
      cd14057
      Location:146 → 398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:15 → 46
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 73
      Ank_2; Ankyrin repeats (3 copies)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6662246..6669338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368672.1 → XP_054224647.1  integrin-linked protein kinase isoform X2

    2. XM_054368671.1 → XP_054224646.1  integrin-linked protein kinase isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13418.2 GenPept UniProtKB/Swiss-Prot:Q13418

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