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    Vgll4 vestigial like family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 232334, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vgll4provided by MGI
    Official Full Name
    vestigial like family member 4provided by MGI
    Primary source
    MGI:MGI:2652840
    See related
    Ensembl:ENSMUSG00000030315 AllianceGenome:MGI:2652840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VGL-4
    Summary
    Predicted to enable transcription coactivator binding activity. Involved in several processes, including negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and positive regulation of protein catabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 23.7), lung adult (RPKM 17.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vgll4 in Genome Data Viewer
    Location:
    6 E3; 6 53.07 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114836850..114946932, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114860621..114970007, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene autophagy related 7 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17064 Neighboring gene STARR-positive B cell enhancer ABC_E11331 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114824988-114825171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114825181-114825290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114843851-114843960 Neighboring gene STARR-seq mESC enhancer starr_17069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114870691-114870844 Neighboring gene STARR-positive B cell enhancer ABC_E4855 Neighboring gene STARR-positive B cell enhancer mm9_chr6:114872780-114873081 Neighboring gene STARR-positive B cell enhancer ABC_E4856 Neighboring gene predicted gene, 38876 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene STARR-seq mESC enhancer starr_17075 Neighboring gene STARR-positive B cell enhancer ABC_E6470 Neighboring gene predicted gene, 52944 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Critical role of VGLL4 in the regulation of chronic normobaric hypoxia-induced pulmonary hypertension in mice. Tian Q, et al. FASEB J, 2021 Aug. PMID 34314061
    2. Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion. Xie W, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30119884
    3. Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease. Tian Q, et al. FASEB J, 2023 Dec. PMID 37921465
    4. Generation of Vgll4-DreER transgenic mouse for visualizing and manipulating VGLL4-expressing cells in vivo. Zhong Y, et al. J Biochem Mol Toxicol, 2023 Oct. PMID 37352117
    5. Dual function of VGLL4 in muscle regeneration. Feng X, et al. EMBO J, 2019 Sep 2. PMID 31328806, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
      Title: Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
    2. Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.
      Title: Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.
    3. Critical role of VGLL4 in the regulation of chronic normobaric hypoxia-induced pulmonary hypertension in mice.
      Title: Critical role of VGLL4 in the regulation of chronic normobaric hypoxia-induced pulmonary hypertension in mice.
    4. Studies identified VGLL4 as a novel activator in regulating muscle regeneration at the differentiation stage, which provides new insights into the YAP-independent role of VGLL4 in skeletal muscle regeneration.
      Title: Dual function of VGLL4 in muscle regeneration.
    5. VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2, and this TEAD4-VGLL4-CtBP2 ternary complex dynamically existed at the early stage of adipogenesis.
      Title: The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.
    6. Results revealed an essential role of VGLL4 in heart valve morphogenesis via regulating valvar interstitial cells proliferation and apoptosis. Furthermore, its deletion resulted in progressive valve disease. These findings suggest that mutations in VGLL4 may underlie human congenital heart valve dysplasia.
      Title: VGLL4 plays a critical role in heart valve development and homeostasis.
    7. Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma in a mouse model with G2/M phase arrest and apoptosis promotion.
      Title: Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion.
    8. VGLL4 inhibits cardiomyocyte proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for degradation.
      Title: Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth.
    9. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes
      Title: Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC54805

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription cofactor vestigial-like protein 4
    Names
    vestigial like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356371.2 → NP_001343300.1  transcription cofactor vestigial-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149276
      UniProtKB/TrEMBL
      D3Z130, Q3TQI9
      Related
      ENSMUSP00000123139.2, ENSMUST00000147639.8
      Conserved Domains (2) summary
      smart00711
      Location:225 → 240
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8 → 215
      VGLL4; Transcription cofactor vestigial-like protein 4

    2. NM_001411599.1 → NP_001398528.1  transcription cofactor vestigial-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149276
      UniProtKB/TrEMBL
      Q3TQI9

    3. NM_001411600.1 → NP_001398529.1  transcription cofactor vestigial-like protein 4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC149276

    4. NM_001411601.1 → NP_001398530.1  transcription cofactor vestigial-like protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC149276
      UniProtKB/TrEMBL
      Q3TSJ2

    5. NM_001411602.1 → NP_001398531.1  transcription cofactor vestigial-like protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC149276

    6. NM_177683.4 → NP_808351.1  transcription cofactor vestigial-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_808351.1

      Status: VALIDATED

      Source sequence(s)
      AC149276
      Consensus CDS
      CCDS20436.1
      UniProtKB/Swiss-Prot
      Q80V24
      Related
      ENSMUSP00000032459.8, ENSMUST00000032459.14
      Conserved Domains (2) summary
      smart00711
      Location:231 → 246
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:14 → 220
      VGLL4; Transcription cofactor vestigial-like protein 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      114836850..114946932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166060.1 → XP_036021953.1  transcription cofactor vestigial-like protein 4 isoform X2

      Conserved Domains (2) summary
      smart00711
      Location:194 → 209
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8 → 184
      VGLL4; Transcription cofactor vestigial-like protein 4

    2. XM_006506012.3 → XP_006506075.1  transcription cofactor vestigial-like protein 4 isoform X2

      Conserved Domains (2) summary
      smart00711
      Location:194 → 209
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8 → 184
      VGLL4; Transcription cofactor vestigial-like protein 4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V24.1 GenPept UniProtKB/Swiss-Prot:Q80V24

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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