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    Lacc1 laccase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 210808, updated on 28-Oct-2024

    Summary

    Official Symbol
    Lacc1provided by MGI
    Official Full Name
    laccase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2445077
    See related
    Ensembl:ENSMUSG00000044350 AllianceGenome:MGI:2445077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030625A04Rik
    Summary
    Predicted to enable adenosine deaminase activity; copper ion binding activity; and pentosyltransferase activity. Involved in regulation of inflammatory response and regulation of purine nucleotide metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis. Orthologous to human LACC1 (laccase domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.9), liver E18 (RPKM 5.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lacc1 in Genome Data Viewer
    Location:
    14 D3; 14 40.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77261640..77274344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77021739..77036929, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37199 Neighboring gene STARR-seq mESC enhancer starr_37200 Neighboring gene predicted gene, 30365 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77411648-77411949 Neighboring gene STARR-seq mESC enhancer starr_37202 Neighboring gene STARR-seq mESC enhancer starr_37203 Neighboring gene STARR-positive B cell enhancer ABC_E5459 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37204 Neighboring gene coiled-coil domain containing 122 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77541449-77541750 Neighboring gene STARR-seq mESC enhancer starr_37206 Neighboring gene ecto-NOX disulfide-thiol exchanger 1 Neighboring gene STARR-seq mESC enhancer starr_37207 Neighboring gene STARR-seq mESC enhancer starr_37208 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2'-deoxyadenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables S-methyl-5-thioadenosine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables S-methyl-5-thioadenosine phosphorylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenosine deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanosine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanosine phosphorylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables purine-nucleoside phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables purine-nucleoside phosphorylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    purine nucleoside phosphorylase LACC1
    Names
    S-methyl-5'-thioadenosine phosphorylase LACC1
    adenosine deaminase LACC1
    fatty acid metabolism-immunity nexus
    guanosine phosphorylase LACC1
    laccase (multicopper oxidoreductase) domain containing 1
    laccase domain-containing protein 1
    NP_766076.1
    XP_030103569.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172488.2NP_766076.1  purine nucleoside phosphorylase LACC1

      See identical proteins and their annotated locations for NP_766076.1

      Status: PROVISIONAL

      Source sequence(s)
      AK033565
      Consensus CDS
      CCDS27287.1
      UniProtKB/Swiss-Prot
      Q14AQ3, Q3U600, Q8BZT9
      Related
      ENSMUSP00000059173.9, ENSMUST00000062789.15
      Conserved Domains (1) summary
      pfam02578
      Location:218426
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      77261640..77274344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247709.2XP_030103569.1  purine nucleoside phosphorylase LACC1 isoform X1

      Conserved Domains (1) summary
      pfam02578
      Location:5170
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

    RNA

    1. XR_003950831.2 RNA Sequence

    2. XR_383153.5 RNA Sequence