Estradiol effect on MCF7 breast cancer cells expressing progesterone receptor-B
Summary:
Analysis of estradiol-treated, progesterone receptor (PR)-low/estrogen receptor (ER)+ MCF7 breast cancer cells stably-expressing PR-B. Progesterone and estrogen are major drivers of breast cancer. Results provide insight into the molecular cross-talk between ER and PR-B in breast cancer.
Daniel AR, Gaviglio AL, Knutson TP, Ostrander JH et al. Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 2015 Jan 22;34(4):506-15. PMID: 24469035