Abstract
A 5-year-old, spayed female cat was referred because of a mass in the cranial mediastinum noted on thoracic radiographs. A thymoma was diagnosed following ultrasound and biopsy of the mass. Treatment was initiated with coarse-fraction radiation therapy using external-beam therapy (four fractions of 5 Gy). The mass responded, but granulocytopenia developed. Bone marrow examination showed a myeloid to erythroid ratio of approximately 1:1, with a left shift within the myeloid line. These findings, as well as the lack of toxic changes within the peripheral blood neutrophils, suggested immune-mediated destruction of peripheral granulocytes. Immune suppression with prednisone and cyclosporine was instituted. After 7 weeks, the neutrophil count returned to normal. The tumor was removed, and cyclosporine was reduced and eventually discontinued 3 weeks postsurgery.
MeSH terms
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Agranulocytosis / complications
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Agranulocytosis / diagnostic imaging
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Agranulocytosis / drug therapy
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Agranulocytosis / veterinary*
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Cat Diseases / diagnosis*
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Cat Diseases / therapy*
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Cats
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Cyclosporine / administration & dosage
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Female
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Immunologic Deficiency Syndromes / complications
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Immunologic Deficiency Syndromes / veterinary
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Immunosuppressive Agents / administration & dosage
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Neutropenia / etiology
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Neutropenia / veterinary
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Prednisone / administration & dosage
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Radiation Injuries / drug therapy
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Radiation Injuries / veterinary
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Radiography
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Thymoma / complications
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Thymoma / diagnosis
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Thymoma / therapy
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Thymoma / veterinary*
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Thymus Neoplasms / complications
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Thymus Neoplasms / diagnosis
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Thymus Neoplasms / therapy
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Thymus Neoplasms / veterinary*
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Treatment Outcome
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Washington
Substances
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Anti-Inflammatory Agents
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Immunosuppressive Agents
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Cyclosporine
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Prednisone