Fish oil supplementation with and without added vitamin E differentially modulates plasma antioxidant concentrations in healthy women

Lipids. 1998 Dec;33(12):1163-7. doi: 10.1007/s11745-998-0319-2.

Abstract

The purpose of this study was to assess the effect of fish oil with or without vitamin E on plasma vitamin antioxidants. Thirty-three apparently healthy women aged 18-28 yr were recruited from the university environs, and 30 completed the double-blinded, parallel design supplementation trial. Blood samples were collected at baseline (week 0) and following 28 d of supplementation with three capsules/d (0.8 g x 3) of either fish oil (FO) or FO with vitamin E (3 IU/g) (FOE). An additional blood sample was taken at day 91 (washout). Plasma antioxidant vitamins, fatty acid composition, and lipid peroxides were measured. Plasma alpha-tocopherol concentrations were increased significantly in both groups postsupplementation FO (P = 0.018) and FOE (P = 0.003) compared with baseline and washout values. Plasma retinol concentration was significantly increased (P = 0.034) compared with baseline and washout values following supplementation with FOE but not FO, while plasma beta-carotene was significantly increased (P = 0.036), compared with baseline and washout values, following supplementation with FO but not FOE. There was a trend (P = 0.059) toward decreased plasma ascorbic acid following FO supplementation compared with baseline and washout. Plasma lipid peroxides did not change following either supplementation. Results suggest that low-dose FO feeding with and without vitamin E differentially modulates plasma antioxidant vitamins but has no significant effect on lipid peroxidation.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / metabolism*
  • Double-Blind Method
  • Energy Intake
  • Female
  • Fish Oils / administration & dosage*
  • Humans
  • Lipid Peroxides / blood
  • Reference Values
  • Vitamin E / administration & dosage*

Substances

  • Antioxidants
  • Fish Oils
  • Lipid Peroxides
  • Vitamin E