Does overexpression of betaAPP in aging muscle have a pathogenic role and a relevance to Alzheimer's disease? Clues from inclusion body myositis, cultured human muscle, and transgenic mice

Am J Pathol. 1998 Dec;153(6):1673-7. doi: 10.1016/s0002-9440(10)65680-5.

Authors

V Askanas¹, W K Engel

Affiliation

¹ Neuromuscular Center, Department of Neurology, University of Southern California School of Medicine, Good Samaritan Hospital, Los Angeles 90017-1912, USA. askanas@hsc.usc.edu

No abstract available

Publication types

Comment

MeSH terms

Age Factors
Alzheimer Disease / physiopathology*
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism*
Animals
Cells, Cultured
Humans
Mice
Mice, Transgenic
Muscles / cytology
Muscles / metabolism*
Muscles / pathology
Myositis, Inclusion Body / metabolism*
Myositis, Inclusion Body / pathology
RNA, Messenger / metabolism
Transfection

Substances

Amyloid beta-Protein Precursor
RNA, Messenger