Abstract
Bile acids modulate hepatocellular signaling pathways in vitro at physiological concentrations. The present paper provides a brief overview of the effects of bile acids on three key messengers in liver cells: cytosolic free calcium, protein kinase A and protein kinase C.
MeSH terms
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Animals
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Bile Acids and Salts / pharmacology
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Bile Acids and Salts / physiology*
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Calcium / metabolism
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Cytosol / metabolism
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Diglycerides / metabolism
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Enzyme Activation / drug effects
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Humans
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In Vitro Techniques
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Liver / cytology
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Liver / drug effects
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Liver / physiology*
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Protein Kinase C / metabolism
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Taurochenodeoxycholic Acid / pharmacology
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Taurochenodeoxycholic Acid / physiology
Substances
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Bile Acids and Salts
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Diglycerides
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Taurochenodeoxycholic Acid
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ursodoxicoltaurine
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Cyclic AMP-Dependent Protein Kinases
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Protein Kinase C
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Calcium