Effects of bile acids on hepatocellular signaling and secretion

Yale J Biol Med. 1997 Jul-Aug;70(4):341-6.

Abstract

Bile acids modulate hepatocellular signaling pathways in vitro at physiological concentrations. The present paper provides a brief overview of the effects of bile acids on three key messengers in liver cells: cytosolic free calcium, protein kinase A and protein kinase C.

Publication types

  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / pharmacology
  • Bile Acids and Salts / physiology*
  • Calcium / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Cytosol / metabolism
  • Diglycerides / metabolism
  • Enzyme Activation / drug effects
  • Humans
  • In Vitro Techniques
  • Liver / cytology
  • Liver / drug effects
  • Liver / physiology*
  • Protein Kinase C / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Taurochenodeoxycholic Acid / pharmacology
  • Taurochenodeoxycholic Acid / physiology

Substances

  • Bile Acids and Salts
  • Diglycerides
  • Taurochenodeoxycholic Acid
  • ursodoxicoltaurine
  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C
  • Calcium