Dysregulation of mesoprefrontal dopamine neurons induced by acute and repeated phencyclidine administration in the nonhuman primate: implications for schizophrenia

Adv Pharmacol. 1998:42:810-4. doi: 10.1016/s1054-3589(08)60870-4.

Authors

J D Jentsch¹, J D Elsworth, J R Taylor, D E Redmond Jr, R H Roth

Affiliation

¹ Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

PMID: 9328021
DOI: 10.1016/s1054-3589(08)60870-4

No abstract available

MeSH terms

Animals
Clonidine / pharmacology
Dopamine / metabolism*
Frontal Lobe / drug effects
Frontal Lobe / physiology*
Functional Laterality
Haplorhini
Humans
Neurons / drug effects
Neurons / physiology*
Nucleus Accumbens / drug effects
Nucleus Accumbens / physiology
Phencyclidine / pharmacology*
Prefrontal Cortex / drug effects
Prefrontal Cortex / physiology*
Prefrontal Cortex / physiopathology
Rats
Receptors, Adrenergic, alpha-2 / drug effects
Receptors, Adrenergic, alpha-2 / physiology
Schizophrenia / physiopathology*

Substances

Receptors, Adrenergic, alpha-2
Phencyclidine
Clonidine
Dopamine