The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata

M J Raftery; R J Waugh; J H Bowie; J C Wallace; M J Tyler

doi:10.1002/psc.60

The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata

J Pept Sci. 1996 Mar-Apr;2(2):117-24. doi: 10.1002/psc.60.

Authors

M J Raftery¹, R J Waugh, J H Bowie, J C Wallace, M J Tyler

Affiliation

¹ Department of Chemistry, University of Adelaide, South Australia.

PMID: 9225251
DOI: 10.1002/psc.60

Abstract

The granular dorsal glands of the giant tree frog Litoria infrafrenata contain five peptides including caerulein (a known neuropeptide), and four new peptides named franatins 1 (MH+ = 1140 Da), 2 (1423), 3 (2180), 4 (2493). The amino acid sequences of the frenatins are detailed: their structures do not correspond to those of peptides isolated from other amphibians or animals. Frenatin 3, Gly-Leu-Met-Ser-Val-Leu -Gly-His-Ala-Val-Gly-Asn-Val-Leu-Gly-Gly-Leu-Phe-Lys-Ser-(OH), has wide spectrum antimicrobial properties.

MeSH terms

Amino Acid Sequence
Animals
Anura / metabolism*
Molecular Sequence Data
Peptides / chemistry*
Skin / metabolism*

Substances

Peptides