Peptic activity and gastroduodenal mucosal damage

Yale J Biol Med. 1996 Jan-Feb;69(1):85-90.

Abstract

This contribution reviews briefly the history of the discovery and characterization of peptic activity; secretory models and current concepts regarding the regulation of pepsinogen secretion; and evidence that pepsin is a necessary co-factor for gastroduodenal mucosal injury. Several animal studies indicate that peptic activity is required for acid- and nonsteroidal anti-inflammatory drug-induced gastroduodenal ulceration. A more vigorous approach to the development of anti-peptic drugs for the treatment of peptic ulcer disease is encouraged.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Duodenum / drug effects*
  • Duodenum / pathology*
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / pathology*
  • Humans
  • Intestinal Mucosa / drug effects*
  • Intestinal Mucosa / pathology*
  • Pepsin A / adverse effects*

Substances

  • Pepsin A