The radiation chemistry of d(CpGpTpA) in the presence of oxygen

Radiat Res. 1995 Apr;142(1):107-9.

Abstract

This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA Damage*
  • Oligodeoxyribonucleotides / radiation effects*
  • Oxygen / pharmacology*

Substances

  • Oligodeoxyribonucleotides
  • Oxygen