Abstract
Although there is an abundance of evidence which indicates that ATP is released as well as taken up by cells, the concept that ATP cannot cross the cell membrane has tended to prevail. This article reviews the evidence for the release as well as uptake of ATP by cells. The evidence presented by various investigators clearly indicates that ATP can cross the cell membrane and suggests that the release and uptake of ATP are physiological processes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenosine / metabolism
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Adenosine Diphosphate / metabolism
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Adenosine Monophosphate / metabolism
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Adenosine Triphosphate / metabolism*
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Adenosine Triphosphate / physiology
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Animals
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Biological Transport
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Cell Membrane Permeability*
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Central Nervous System / metabolism
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Guinea Pigs
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Humans
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Hypoxia / metabolism
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Muscles / physiology
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Rats
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Sensory Receptor Cells / metabolism
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Sensory Receptor Cells / physiology
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Vasodilation
Substances
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Adenosine Monophosphate
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Adenosine Diphosphate
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Adenosine Triphosphate
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Adenosine