Abstract
Numerous systemic diseases share immunopathogenic mechanisms. This article reviews the proposed etiologies and immunopathogenic mechanisms of a group of diseases which share pulmonary and renal abnormalities. Specifically, we discuss the following diseases: Good-pasture's syndrome, systemic lupus erythematosus, progressive systemic sclerosis, Wegener's granulomatosis, lymphomatoid granulomatosis, and Churg-Strauss syndrome.
MeSH terms
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Animals
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Anti-Glomerular Basement Membrane Disease / etiology*
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Antibodies, Antinuclear / immunology
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Antigen-Antibody Complex / immunology
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Autoimmune Diseases
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Basement Membrane / immunology
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Collagen Diseases / etiology*
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Diseases in Twins
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Eosinophilia / immunology
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Glomerulonephritis / immunology
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Granulomatosis with Polyangiitis / etiology*
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Haplorhini
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Humans
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Hypersensitivity, Delayed / immunology
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Immunoglobulin E / immunology
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Kidney Glomerulus / immunology
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Langerhans Cells / cytology
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Lupus Erythematosus, Systemic / etiology
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Lymphokines / immunology
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Lymphomatoid Granulomatosis / etiology*
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Macrophages / immunology
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Neutrophils / immunology
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Pulmonary Alveoli / cytology
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Scleroderma, Systemic / etiology
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Sheep
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T-Lymphocytes / immunology
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Vasculitis, Leukocytoclastic, Cutaneous / etiology*
Substances
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Antibodies, Antinuclear
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Antigen-Antibody Complex
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Lymphokines
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Immunoglobulin E