Neuronal models in temperature regulation are primarily considered explicit statements of assumptions and premises used in design of experiments and development of descriptive equations concerning the relationships between thermal inputs and control actions. Some of the premises of current multiplicative models are discussed in relation to presently available experimental evidence. The results of these experiments suggest that there is no skin temperature compatible with life which completely suppresses a rise of heat production in response to low internal temperature. The slope of heat production versus internal temperature at a given skin temperature is not constant but depends on internal temperature and the level of heat production. Therefore, a concept involving additive interaction of central and peripheral temperature signals appears more flexible in accepting data obtained even under extreme conditions.