Is prostaglandin E2 involved in the pathogenesis of fever? Effects of interleukin-1 on the release of prostaglandins

Yale J Biol Med. 1986 Mar-Apr;59(2):151-8.

Abstract

Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid. In addition, IL-1 increases the synthesis of cyclooxygenase, as evidenced by the increased conversion of arachidonic acid into prostaglandins after fibroblasts are pre-incubated with IL-1. Evidence is also presented that fever is caused by interleukin-1-induced prostaglandin E2.

MeSH terms

  • Animals
  • Brain / physiology
  • Brain / physiopathology
  • Dinoprostone
  • Fever / physiopathology*
  • Fibroblasts / physiology
  • Humans
  • Inflammation
  • Interleukin-1 / physiology*
  • Monocytes / physiology
  • Muscles / physiopathology
  • Neurons / physiology
  • Prostaglandins / metabolism*
  • Prostaglandins E / physiology*
  • Starvation

Substances

  • Interleukin-1
  • Prostaglandins
  • Prostaglandins E
  • Dinoprostone