Abstract
IRIS is a phenomenon describing localized inflammatory reactions at BCG vaccination site and development of lymphadenopathy as immune system recovers. It is a rare entity in children following haploidentical HSCT. We represent the successful treatment of a case with fluctuating lymphadenopathy due to BCG vaccine during immune reconstitution period following ex vivo T-cell-depleted haploidentical HSCT.
Keywords:
BCG; HSCT; Haploidentical; IRIS.
© 2019 Wiley Periodicals, Inc.
MeSH terms
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Antitubercular Agents / therapeutic use
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BCG Vaccine / adverse effects*
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Female
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Hematopoietic Stem Cell Transplantation*
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Humans
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Immune Reconstitution Inflammatory Syndrome / drug therapy*
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Immune Reconstitution Inflammatory Syndrome / etiology*
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Infant
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Lymphocyte Depletion
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Severe Combined Immunodeficiency / immunology
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Severe Combined Immunodeficiency / therapy*
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T-Lymphocytes / immunology
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Tuberculosis, Lymph Node / drug therapy
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Tuberculosis, Lymph Node / immunology
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Turkey
Substances
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Antitubercular Agents
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BCG Vaccine