Successful treatment of BCG-related immune reconstitution inflammatory syndrome following ex vivo T-cell-depleted haploidentical hematopoietic stem cell transplantation: A case report

Pediatr Transplant. 2019 Aug;23(5):e13464. doi: 10.1111/petr.13464. Epub 2019 May 12.

Abstract

IRIS is a phenomenon describing localized inflammatory reactions at BCG vaccination site and development of lymphadenopathy as immune system recovers. It is a rare entity in children following haploidentical HSCT. We represent the successful treatment of a case with fluctuating lymphadenopathy due to BCG vaccine during immune reconstitution period following ex vivo T-cell-depleted haploidentical HSCT.

Keywords: BCG; HSCT; Haploidentical; IRIS.

Publication types

  • Case Reports

MeSH terms

  • Antitubercular Agents / therapeutic use
  • BCG Vaccine / adverse effects*
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immune Reconstitution Inflammatory Syndrome / drug therapy*
  • Immune Reconstitution Inflammatory Syndrome / etiology*
  • Infant
  • Lymphocyte Depletion
  • Severe Combined Immunodeficiency / immunology
  • Severe Combined Immunodeficiency / therapy*
  • T-Lymphocytes / immunology
  • Tuberculosis, Lymph Node / drug therapy
  • Tuberculosis, Lymph Node / immunology
  • Turkey

Substances

  • Antitubercular Agents
  • BCG Vaccine